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Mitotic checkpoint complex [cytosol]
Stable Identifier
R-SSC-377882
Type
Complex
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Sus scrofa)
Cell Cycle Checkpoints (Sus scrofa)
Mitotic Spindle Checkpoint (Sus scrofa)
Amplification of signal from the kinetochores (Sus scrofa)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Sus scrofa)
MAD2 associates with the Mad1 kinetochore complex (Sus scrofa)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
Mad1:kinetochore complex [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Mad1:kinetochore complex [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
MAD2 converted to an inhibitory state via interaction with Mad1 (Sus scrofa)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
Mad1:kinetochore complex [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Mad1 binds kinetochore (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Mad1:kinetochore complex [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Release of activated MAD2 from kinetochores (Sus scrofa)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
Mad1:kinetochore complex [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Mad1:kinetochore complex [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Sus scrofa)
Inactivation of APC/C via direct inhibition of the APC/C complex (Sus scrofa)
Binding of the MCC complex to the APC/C complex (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Formation of the MCC complex (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Cell Cycle, Mitotic (Sus scrofa)
M Phase (Sus scrofa)
Mitotic Metaphase and Anaphase (Sus scrofa)
Mitotic Anaphase (Sus scrofa)
Separation of Sister Chromatids (Sus scrofa)
ESPL1 (Separase) cleaves centromeric cohesin (Sus scrofa)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
Microtubule-bound kinetochore [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Separation of sister chromatids (Sus scrofa)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Mitotic Prometaphase (Sus scrofa)
EML4 and NUDC in mitotic spindle formation (Sus scrofa)
EML4 recruits NUDC to mitotic spindle (Sus scrofa)
Microtubule-bound kinetochore [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Sus scrofa)
Microtubule-bound kinetochore [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Kinetochore capture of astral microtubules (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Microtubule-bound kinetochore [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Resolution of Sister Chromatid Cohesion (Sus scrofa)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
Microtubule-bound kinetochore [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Kinetochore assembly (Sus scrofa)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Microtubule-bound kinetochore [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
Microtubule-bound kinetochore [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
Microtubule-bound kinetochore [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
Microtubule-bound kinetochore [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
Microtubule-bound kinetochore [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Regulation of mitotic cell cycle (Sus scrofa)
APC/C-mediated degradation of cell cycle proteins (Sus scrofa)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Sus scrofa)
APC-Cdc20 mediated degradation of Nek2A (Sus scrofa)
Degradation of multiubiquitinated Nek2A (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Multiubiquitinated Nek2A [cytosol] (Sus scrofa)
Nek2A:MCC:APC/C complex [cytosol] (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Multiubiquitination of Nek2A (Sus scrofa)
Multiubiquitinated Nek2A [cytosol] (Sus scrofa)
Nek2A:MCC:APC/C complex [cytosol] (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Nek2A:MCC:APC/C complex [cytosol] (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Sus scrofa)
Association of Cyclin A with the APC/C (Sus scrofa)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Degradation multiubiquitinated Cyclin A (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Sus scrofa)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Sus scrofa)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Sus scrofa)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Regulation of APC/C activators between G1/S and early anaphase (Sus scrofa)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Sus scrofa)
Inactivation of APC/C via direct inhibition of the APC/C complex (Sus scrofa)
Binding of the MCC complex to the APC/C complex (Sus scrofa)
MCC:APC/C complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Formation of the MCC complex (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
Signaling by Rho GTPases (Sus scrofa)
RHO GTPase Effectors (Sus scrofa)
RHO GTPases Activate Formins (Sus scrofa)
AURKB phosphorylates DIAPH2-2 at kinetochores (Sus scrofa)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
Microtubule-bound kinetochore [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Mitotic checkpoint complex [cytosol] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
BUB1B [cytosol]
(Sus scrofa)
BUB3 [cytosol]
(Sus scrofa)
CDC20 [cytosol]
(Sus scrofa)
MAD2L1 [cytosol]
(Sus scrofa)
Participates
as an input of
Binding of the MCC complex to the APC/C complex (Sus scrofa)
as an output of
Formation of the MCC complex (Sus scrofa)
as a component of
MCC:APC/C complex [cytosol] (Sus scrofa)
Kinetochore [cytosol] (Sus scrofa)
Inferred From
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol]
(Homo sapiens)
Mitotic checkpoint complex [cytosol]
(Homo sapiens)
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