Reactome | SOCS1 [cytosol]

SOCS1 [cytosol]

Stable Identifier

R-SSC-204910

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

SOCS1, E7CR04

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Class I MHC mediated antigen processing & presentation (Sus scrofa)
    - Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
      - Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
      - Polyubiquitination of substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
      - Release of E3 from polyubiquitinated substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
      - Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
- Cytokine Signaling in Immune system (Sus scrofa)
  - Interferon Signaling (Sus scrofa)
    - Interferon alpha/beta signaling (Sus scrofa)
      - Activation of JAK kinases (Sus scrofa)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Sus scrofa)
        
        p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
    - Interferon gamma signaling (Sus scrofa)
      - Regulation of IFNG signaling (Sus scrofa)
        
        SOCS-1 and SOCS-3 binds to p-JAK2 (Sus scrofa)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
      - Transphosphorylation of JAK1 (Sus scrofa)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-4 and Interleukin-13 signaling (Sus scrofa)
      - SOCS5,(SOCS1) bind IL4RA (Sus scrofa)
        
        IL4:IL4R:JAK2:IL13RA:TYK2:SOCS5,(SOCS1) [plasma membrane] (Sus scrofa)
        
        SOCS5,(SOCS1) [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)
        
        SOCS5,(SOCS1) [cytosol] (Sus scrofa)
        
        SOCS1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:E7CR04

Gene Names

SOCS1

Reference Genes

BioGPS Gene:100307052 SOCS1

ENSEMBL:ENSSSCG00000027855.4

KEGG Gene (Sus scrofa):100307052 SOCS1

Monarch:100307052 SOCS1

NCBI Gene:100307052 SOCS1

Reference Transcript

Other Identifiers

100307052

GO:0001817

GO:0001932

GO:0002376

GO:0005159

GO:0005634

GO:0005654

GO:0005942

GO:0006629

GO:0007155

GO:0007259

GO:0009968

GO:0016567

GO:0019210

GO:0019221

GO:0019901

GO:0023052

GO:0030154

GO:0030225

GO:0035556

GO:0036211

GO:0036464

GO:0042509

GO:0042532

GO:0043226

GO:0043372

GO:0043377

GO:0045444

GO:0045591

GO:0046425

GO:0046426

GO:0046627

GO:0046854

GO:0046935

GO:0048856

GO:0071230

GO:0098772

Ssc.26216.2.A1_at

Ssc.9016.1.A1_at

Participates

as a candidate of

SOCS5,(SOCS1) [cytosol] (Sus scrofa)

as a member of

SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)

Inferred From

SOCS1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001191697.1, XP_005662183.1, XP_005662182.1

OpenTargets

ENSG00000185338

Ensembl

ENSSSCP00000024749, ENSSSCG00000027855, ENSSSCT00000029636

VGNC

93330

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