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About
What is Reactome ?
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phospho-p-Y542,Y580-PTPN11 [cytosol]
Stable Identifier
R-SSC-162573
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
A0A480LMF4
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by CSF3 (G-CSF) (Sus scrofa)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Sus scrofa)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-6 family signaling (Sus scrofa)
Interleukin-6 signaling (Sus scrofa)
PTPN11 is phosphorylated (Sus scrofa)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
Negative regulation of the PI3K/AKT network (Sus scrofa)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activator:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activator:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
MAPK family signaling cascades (Sus scrofa)
MAPK1/MAPK3 signaling (Sus scrofa)
RAF-independent MAPK1/3 activation (Sus scrofa)
MAPK1 (ERK2) activation (Sus scrofa)
MAP2K2 binds MAPK1 (Sus scrofa)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by FGFR (Sus scrofa)
Signaling by FGFR1 (Sus scrofa)
Downstream signaling of activated FGFR1 (Sus scrofa)
FRS-mediated FGFR1 signaling (Sus scrofa)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Sus scrofa)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
PI-3K cascade:FGFR1 (Sus scrofa)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Negative regulation of FGFR1 signaling (Sus scrofa)
CBL ubiquitinates FRS2 and FGFR1 (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Signaling by FGFR2 (Sus scrofa)
Downstream signaling of activated FGFR2 (Sus scrofa)
FRS-mediated FGFR2 signaling (Sus scrofa)
Activated FGFR2 phosphorylates PPTN11 (Sus scrofa)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
PI-3K cascade:FGFR2 (Sus scrofa)
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Negative regulation of FGFR2 signaling (Sus scrofa)
CBL ubiquitinates FRS2 and FGFR2 (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Signaling by FGFR3 (Sus scrofa)
Downstream signaling of activated FGFR3 (Sus scrofa)
FRS-mediated FGFR3 signaling (Sus scrofa)
Activated FGFR3 phosphorylates PPTN11 (Sus scrofa)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
PI-3K cascade:FGFR3 (Sus scrofa)
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Negative regulation of FGFR3 signaling (Sus scrofa)
CBL ubiquitinates FRS2 and FGFR3 (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Signaling by FGFR4 (Sus scrofa)
Downstream signaling of activated FGFR4 (Sus scrofa)
FRS-mediated FGFR4 signaling (Sus scrofa)
Activated FGFR4 phosphorylates PPTN11 (Sus scrofa)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
PI-3K cascade:FGFR4 (Sus scrofa)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Negative regulation of FGFR4 signaling (Sus scrofa)
CBL ubiquitinates FRS2 and FGFR4 (Sus scrofa)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Sus scrofa)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Signaling by Insulin receptor (Sus scrofa)
Insulin receptor signalling cascade (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
PI3K-containing complexes [cytosol] (Sus scrofa)
Activated FGFR bound to PI3K [cytosol] (Sus scrofa)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Sus scrofa)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Signaling by SCF-KIT (Sus scrofa)
GRB2 is indirectly recruited to p-KIT through SHP2 (Sus scrofa)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Indirect recruitment of GAB2 to p-KIT (Sus scrofa)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Sus scrofa)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Phosphorylation of GAB2 by SFKs (Sus scrofa)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Phosphorylation of SHP2 by SFKs (Sus scrofa)
p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
IGF1R signaling cascade (Sus scrofa)
IRS-related events triggered by IGF1R (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
PI3K-containing complexes [cytosol] (Sus scrofa)
Activated FGFR bound to PI3K [cytosol] (Sus scrofa)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Sus scrofa)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A480LMF4
Reference Genes
BioGPS Gene:100170851
ENSEMBL:ENSSSCG00000030289.4
Monarch:100170851
NCBI Gene:100170851
Reference Transcript
RefSeq:XM_013990364.1
Other Identifiers
100170851
GO:0000077
GO:0000278
GO:0001784
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005158
GO:0005634
GO:0005737
GO:0006470
GO:0006629
GO:0006641
GO:0006886
GO:0006913
GO:0007155
GO:0007165
GO:0007173
GO:0007229
GO:0007409
GO:0007420
GO:0007507
GO:0008543
GO:0009755
GO:0009967
GO:0016311
GO:0016787
GO:0016791
GO:0019901
GO:0021697
GO:0022414
GO:0023052
GO:0030154
GO:0030159
GO:0030220
GO:0030971
GO:0032331
GO:0032480
GO:0032528
GO:0032728
GO:0032755
GO:0032760
GO:0032991
GO:0033628
GO:0033629
GO:0035264
GO:0035265
GO:0035855
GO:0036211
GO:0036302
GO:0038127
GO:0042445
GO:0042593
GO:0043226
GO:0043254
GO:0043408
GO:0045296
GO:0045778
GO:0045931
GO:0046326
GO:0046628
GO:0046676
GO:0046825
GO:0046887
GO:0046888
GO:0048008
GO:0048011
GO:0048013
GO:0048609
GO:0048806
GO:0048839
GO:0048856
GO:0048870
GO:0048873
GO:0050731
GO:0050839
GO:0050886
GO:0051428
GO:0051463
GO:0055085
GO:0060020
GO:0060090
GO:0060125
GO:0060325
GO:0061582
GO:0065003
GO:0070374
GO:0071310
GO:0071364
GO:0140096
GO:1990782
Ssc.16809.1.S1_at
Ssc.8283.1.A1_at
Participates
as a component of
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
Other forms of this molecule
PTPN11 [nucleoplasm]
PTPN11 [cytosol]
Inferred From
p-Y542,Y580-PTPN11 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 542 (in Homo sapiens)
Coordinate
542
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 580 (in Homo sapiens)
Coordinate
580
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_013845818.1
Ensembl
ENSSSCT00000089137
,
ENSSSCP00000064345
,
ENSSSCG00000030289
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