Reactome | rps2201 [cytosol]

rps2201 [cytosol]

Stable Identifier

R-SPO-72345

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

RPS15A, P0CT58

Locations in the PathwayBrowser

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Metabolism of RNA (Schizosaccharomyces pombe)

- Nonsense-Mediated Decay (NMD) (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
    - SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Schizosaccharomyces pombe)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)

Metabolism of proteins (Schizosaccharomyces pombe)

- Translation (Schizosaccharomyces pombe)
  - Eukaryotic Translation Initiation (Schizosaccharomyces pombe)
    - Cap-dependent Translation Initiation (Schizosaccharomyces pombe)
      - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Schizosaccharomyces pombe)
        
        Translation initiation complex formation (Schizosaccharomyces pombe)
        
        Formation of translation initiation complexes containing mRNA that does not circularize (Schizosaccharomyces pombe)
        
        43S complex [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        48S complex [cytosol] (Schizosaccharomyces pombe)
        
        43S complex [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
      - Formation of a pool of free 40S subunits (Schizosaccharomyces pombe)
        
        Release of 40S and 60S subunits from the 80S ribosome (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        eIF3 and eIF1A bind to the 40S subunit (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        40S:eIF3:eIF1A [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
      - Formation of the ternary complex, and subsequently, the 43S complex (Schizosaccharomyces pombe)
        
        Formation of the 43S pre-initiation complex (Schizosaccharomyces pombe)
        
        40S:eIF3:eIF1A [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        43S complex [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Schizosaccharomyces pombe)
        
        The 60S subunit joins the translation initiation complex (Schizosaccharomyces pombe)
        
        40S:Met-tRNAi:mRNA [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        eIF2:GTP is hydrolyzed, eIFs are released (Schizosaccharomyces pombe)
        
        40S:Met-tRNAi:mRNA [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        48S complex [cytosol] (Schizosaccharomyces pombe)
        
        43S complex [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        eIF5B:GTP is hydrolyzed and released (Schizosaccharomyces pombe)
        
        80S:Met-tRNAi:mRNA [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
      - Ribosomal scanning and start codon recognition (Schizosaccharomyces pombe)
        
        Ribosomal scanning (Schizosaccharomyces pombe)
        
        48S complex [cytosol] (Schizosaccharomyces pombe)
        
        43S complex [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        Start codon recognition (Schizosaccharomyces pombe)
        
        48S complex [cytosol] (Schizosaccharomyces pombe)
        
        43S complex [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Schizosaccharomyces pombe)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Schizosaccharomyces pombe)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Schizosaccharomyces pombe)
        
        43S complex [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Schizosaccharomyces pombe)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Schizosaccharomyces pombe)
        
        43S complex [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
  - SRP-dependent cotranslational protein targeting to membrane (Schizosaccharomyces pombe)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Schizosaccharomyces pombe)
      - SRP:polypeptide+signal:ribosome [cytosol] (Schizosaccharomyces pombe)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)
        
        rps2201 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:P0CT58

Gene Names

rps2201

Reference Genes

BioGPS Gene:2541838 rps2201

ENSEMBL:SPAC22A12.04c

GeneDB:SPAC22A12.04c

KEGG Gene (Schizosaccharomyces pombe):SPAC22A12.04c rps2201

Monarch:2541838 rps2201

NCBI Gene:2541838 rps2201

Reference Transcript

Participates

as a member of

Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)

Other forms of this molecule

rps2201 [nucleoplasm]

Inferred From

RPS15A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_593234.1, NP_593367.1

PRO

P0CT58

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