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mad2 [cytosol]
Stable Identifier
R-SPO-141447
Type
Protein [EntityWithAccessionedSequence]
Species
Schizosaccharomyces pombe
Compartment
cytosol
Synonyms
Activated MAD2L1, O14417
Locations in the PathwayBrowser
Expand all
Cell Cycle (Schizosaccharomyces pombe)
Cell Cycle Checkpoints (Schizosaccharomyces pombe)
Mitotic Spindle Checkpoint (Schizosaccharomyces pombe)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Schizosaccharomyces pombe)
Inactivation of APC/C via CDC20 sequestration (Schizosaccharomyces pombe)
MAD2*CDC20 complex [cytosol] (Schizosaccharomyces pombe)
mad2 [cytosol] (Schizosaccharomyces pombe)
mad2 [cytosol] (Schizosaccharomyces pombe)
Inactivation of APC/C via direct inhibition of the APC/C complex (Schizosaccharomyces pombe)
Formation of the MCC complex (Schizosaccharomyces pombe)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Schizosaccharomyces pombe)
mad2 [cytosol] (Schizosaccharomyces pombe)
mad2 [cytosol] (Schizosaccharomyces pombe)
Cell Cycle, Mitotic (Schizosaccharomyces pombe)
Regulation of mitotic cell cycle (Schizosaccharomyces pombe)
APC/C-mediated degradation of cell cycle proteins (Schizosaccharomyces pombe)
Regulation of APC/C activators between G1/S and early anaphase (Schizosaccharomyces pombe)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Schizosaccharomyces pombe)
Inactivation of APC/C via CDC20 sequestration (Schizosaccharomyces pombe)
MAD2*CDC20 complex [cytosol] (Schizosaccharomyces pombe)
mad2 [cytosol] (Schizosaccharomyces pombe)
mad2 [cytosol] (Schizosaccharomyces pombe)
Inactivation of APC/C via direct inhibition of the APC/C complex (Schizosaccharomyces pombe)
Formation of the MCC complex (Schizosaccharomyces pombe)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Schizosaccharomyces pombe)
mad2 [cytosol] (Schizosaccharomyces pombe)
mad2 [cytosol] (Schizosaccharomyces pombe)
External Reference Information
External Reference
UniProt:O14417
Gene Names
mad2
Reference Genes
BioGPS Gene:2540589 mad2
ENSEMBL:SPBC20F10.06
GeneDB:SPBC20F10.06
KEGG Gene (Schizosaccharomyces pombe):SPBC20F10.06 mad2
Monarch:2540589 mad2
NCBI Gene:2540589 mad2
Reference Transcript
RefSeq:NM_001022291.2 mad2
Participates
as an input of
Inactivation of APC/C via CDC20 sequestration (Schizosaccharomyces pombe)
Formation of the MCC complex (Schizosaccharomyces pombe)
as a component of
MAD2*CDC20 complex [cytosol] (Schizosaccharomyces pombe)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Schizosaccharomyces pombe)
Inferred From
Activated MAD2L1 [cytosol]
(Homo sapiens)
MAD2L1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_596370.1
PRO
O14417
PDB
4AEZ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O59767 MAD3
0.764
5
UniProt:P78972
2
slp1 [nucleoplasm]
(R-SPO-174112)
slp1 [cytosol]
(R-SPO-141412)
0.756
8
UniProt:P87169
1
mad1 [cytosol]
(R-SPO-141433)
0.573
4
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