Reactome | RPL1A [cytosol]

RPL1A [cytosol]

Stable Identifier

R-SCE-9633145

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

fullName evidence="11"60S ribosomal protein L1-A, RL1A_YEAST

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPL1A,B [cytosol] (Saccharomyces cerevisiae)
        
        RPL1A [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPL1A,B [cytosol] (Saccharomyces cerevisiae)
        
        RPL1A [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPL1A,B [cytosol] (Saccharomyces cerevisiae)
        
        RPL1A [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPL1A,B [cytosol] (Saccharomyces cerevisiae)
        
        RPL1A [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPL1A,B [cytosol] (Saccharomyces cerevisiae)
        
        RPL1A [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P0CX43 RPL1A

Gene Names

RPL1A, SSM1, SSM1A, YPL220W

Chain

initiator methionine:, chain:2-217

Reference Genes

BioGPS Gene:852742 RPL1A

BioGPS Gene:855881 RPL1A

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YGL135W RPL1A

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YPL220W RPL1A

Monarch:852742 RPL1A

Monarch:855881 RPL1A

NCBI Gene:852742 RPL1A

NCBI Gene:855881 RPL1A

Reference Transcript

Other Identifiers

1779233_s_at

7984_s_at

852742

855881

GO:0000054

GO:0000055

GO:0000470

GO:0002181

GO:0003674

GO:0003723

GO:0003735

GO:0005198

GO:0005575

GO:0005737

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0008150

GO:0015934

GO:0022625

GO:0042273

GO:0051169

GO:1990904

Participates

as a member of

RPL1A,B [cytosol] (Saccharomyces cerevisiae)

Inferred From

RPL10A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_015104.1, NP_011380.3

PRO

P0CX43

PDB

6YLG, 3J0Q, 4V7R, 6YLH, 3J0P, 4V4B, 7NAC, 8AGX, 8AGV, 5JUU, 3J77, 6R84, 8BQX, 3J6Y, 5JUO, 6GQB, 3J6X, 4V6I, 8AGU, 6GQV, 5JUS, 6TB3, 5JCS, 6R86, 8HFR, 3J78, 5JUP, 6WOO, 8AGT, 2NOQ, 7R7C, 4V7H, 8BQD, 8AAF, 7ZW0, 6OIG, 7R7A, 4V7F, 4V91, 5JUT, 8AGZ, 8AGW, 6R87

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