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ORC5 [nucleoplasm]
Stable Identifier
R-SCE-68516
Type
Protein [EntityWithAccessionedSequence]
Species
Saccharomyces cerevisiae
Compartment
nucleoplasm
Synonyms
P50874
Locations in the PathwayBrowser
Expand all
Cell Cycle (Saccharomyces cerevisiae)
Cell Cycle Checkpoints (Saccharomyces cerevisiae)
G2/M Checkpoints (Saccharomyces cerevisiae)
Activation of ATR in response to replication stress (Saccharomyces cerevisiae)
Loading of claspin onto DNA during replication origin firing (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
Cell Cycle, Mitotic (Saccharomyces cerevisiae)
Mitotic G1 phase and G1/S transition (Saccharomyces cerevisiae)
G1/S Transition (Saccharomyces cerevisiae)
Activation of the pre-replicative complex (Saccharomyces cerevisiae)
CDK and DDK associate with the Mcm10:pre-replicative complex (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
Cdc45 associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
DNA polymerase alpha:primase binds at the origin (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
DNA polymerase epsilon binds at the origin (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Saccharomyces cerevisiae)
MCM10:pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
DNA Replication (Saccharomyces cerevisiae)
DNA Replication Pre-Initiation (Saccharomyces cerevisiae)
Activation of the pre-replicative complex (Saccharomyces cerevisiae)
CDK and DDK associate with the Mcm10:pre-replicative complex (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
Cdc45 associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
DNA polymerase alpha:primase binds at the origin (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
DNA polymerase epsilon binds at the origin (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
MCM10:active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
active pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Saccharomyces cerevisiae)
MCM10:pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
pre-replicative complex [nucleoplasm] (Saccharomyces cerevisiae)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
CDC6:ORC:origin complex [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
Assembly of the pre-replicative complex (Saccharomyces cerevisiae)
Assembly of the ORC complex at the origin of replication (Saccharomyces cerevisiae)
Formation of ORC(1-5) complex (Saccharomyces cerevisiae)
ORC(1-5):origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC(1-5) [nucleoplasm] (Saccharomyces cerevisiae)
ORC(2-5) [nucleoplasm] (Saccharomyces cerevisiae)
ORC2:ORC3:ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC(2-5) [nucleoplasm] (Saccharomyces cerevisiae)
ORC2:ORC3:ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
Formation of ORC(2-5) complex (Saccharomyces cerevisiae)
ORC(2-5) [nucleoplasm] (Saccharomyces cerevisiae)
ORC2:ORC3:ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC2:ORC3:ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 binds ORC2:ORC3 (Saccharomyces cerevisiae)
ORC2:ORC3:ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
CDC6 association with the ORC:origin complex (Saccharomyces cerevisiae)
CDC6 association with ORC(1-6) at replication origins (Saccharomyces cerevisiae)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC(1-6):origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC(1-5):origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC(1-5) [nucleoplasm] (Saccharomyces cerevisiae)
ORC(2-5) [nucleoplasm] (Saccharomyces cerevisiae)
ORC2:ORC3:ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC(1-6):origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC(1-5):origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
ORC(1-5) [nucleoplasm] (Saccharomyces cerevisiae)
ORC(2-5) [nucleoplasm] (Saccharomyces cerevisiae)
ORC2:ORC3:ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
External Reference Information
External Reference
UniProt:P50874 ORC5
Gene Names
ORC5, YNL261W, N0834
Chain
chain:1-479
Reference Genes
BioGPS Gene:855460 ORC5
KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YNL261W ORC5
Monarch:855460 ORC5
NCBI Gene:855460 ORC5
Reference Transcript
RefSeq:NM_001183099.1 ORC5
Other Identifiers
1773209_at
855460
9133_at
GO:0000166
GO:0000808
GO:0003674
GO:0003677
GO:0003688
GO:0005515
GO:0005524
GO:0005575
GO:0005634
GO:0005654
GO:0005656
GO:0005664
GO:0005694
GO:0006260
GO:0006267
GO:0006270
GO:0006275
GO:0006325
GO:0008150
GO:0016787
GO:0016887
GO:0030466
GO:0031261
GO:0031938
GO:0035361
GO:0043167
GO:0051052
GO:0140657
Participates
as a component of
pre-replicative complex (Orc1-minus) [nucleoplasm] (Saccharomyces cerevisiae)
ORC2:ORC3:ORC5 [nucleoplasm] (Saccharomyces cerevisiae)
ORC:origin of replication [nucleoplasm] (Saccharomyces cerevisiae)
as an input of
ORC5 binds ORC2:ORC3 (Saccharomyces cerevisiae)
Other forms of this molecule
yORC5 [nucleoplasm]
Inferred From
ORC5 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_014138.1
OpenTargets
ENSG00000164815
PRO
P50874
PDB
7TJH
,
7TJK
,
7TJJ
,
6WGC
,
6WGI
,
7MCA
,
6WGG
,
6RQC
,
7TJI
,
5V8F
,
5ZR1
,
7TJF
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54791 ORC4
2
yORC4 [nucleoplasm]
(R-SCE-9749319)
ORC4 [nucleoplasm]
(R-SCE-68519)
0.788
21
UniProt:P54784 ORC1
6
phospho-PolyUb,p-S,T-ORC1 [cytosol]
(R-SCE-9032195)
phospho-PolyUb,p-S,T-ORC1 [nucleoplasm]
(R-SCE-9032189)
phospho-p-S,T-ORC1 [nucleoplasm]
(R-SCE-68943)
ORC1 [cytosol]
(R-SCE-113840)
yORC1 [nucleoplasm]
(R-SCE-9749323)
ORC1 [nucleoplasm]
(R-SCE-68522)
0.695
10
UniProt:P38826 ORC6
1
yORC6 [nucleoplasm]
(R-SCE-9749321)
0.678
12
UniProt:P32833 ORC2
2
yORC2 [nucleoplasm]
(R-SCE-9749316)
ORC2 [nucleoplasm]
(R-SCE-68405)
0.678
15
UniProt:P09119 CDC6
5
CDC6 [cytosol]
(R-SCE-113566)
phospho-p-CDC6 [cytosol]
(R-SCE-68583)
phospho-p-CDC6 [nucleoplasm]
(R-SCE-5661317)
yCDC6 [nucleoplasm]
(R-SCE-9749328)
CDC6 [nucleoplasm]
(R-SCE-68542)
0.652
3
UniProt:P54790 ORC3
2
yORC3 [nucleoplasm]
(R-SCE-9749325)
ORC3 [nucleoplasm]
(R-SCE-68513)
0.573
6
UniProt:Q06211 MMS1
0.567
4
UniProt:P47050 CUL8
0.567
3
UniProt:Q12495 RLF2
0.547
2
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