Reactome | HSPA8 [cytosol]

HSPA8 [cytosol]

Stable Identifier

R-SCE-264476-4

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P11484

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Saccharomyces cerevisiae)

- Membrane Trafficking (Saccharomyces cerevisiae)
  - Clathrin-mediated endocytosis (Saccharomyces cerevisiae)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Saccharomyces cerevisiae)
      - HSPA8:ATP [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA8 [cytosol] (Saccharomyces cerevisiae)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
        
        HSPA8:ATP [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA8 [cytosol] (Saccharomyces cerevisiae)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Saccharomyces cerevisiae)
      - Homologues of HSPA8 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA8 [cytosol] (Saccharomyces cerevisiae)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
        
        HSPA8:ATP [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA8 [cytosol] (Saccharomyces cerevisiae)
      - clathrin:HSPA8:ADP [cytosol] (Saccharomyces cerevisiae)
        
        HSPA8:ADP [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA8 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P11484

Reference Genes

BioGPS Gene:851369

ENSEMBL:YDL229W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDL229W

Monarch:851369

NCBI Gene:851369

SGD:YDL229W

Reference Transcript

RefSeq:NM_001180289.1

Other Identifiers

3GL1

4932.YDL229W

AAA34692.1

CAA31995.1

CAA98807.1

DAA11637.1

EntrezGene:851369

EntrezGene:SSB1

GO:0000054

GO:0002181

GO:0003674

GO:0005516

GO:0005524

GO:0005575

GO:0005737

GO:0005844

GO:0006364

GO:0006414

GO:0006415

GO:0006450

GO:0006452

GO:0006457

GO:0008150

GO:0015031

GO:0015931

GO:0016787

GO:0016887

GO:0042149

GO:0042594

GO:0043167

GO:0051082

GO:0051083

GO:0051169

IPR013126

IPR018181

IPR029047

IPR029048

M25395

NM_001180289.1

NP_010052.1

PF00012

PR00301

UPI00001682D1

YDL229W

YDL229W_mRNA

Participant Of

hasMember

Homologues of HSPA8 [cytosol]

Other forms of this molecule

HSPA8 [nucleoplasm]

HSPA6 [ficolin-1-rich granule lumen]

HSPA1A [ficolin-1-rich granule lumen]

HSPA8 [ficolin-1-rich granule lumen]

HSPA1A [extracellular region]

HSPA6 [extracellular region]

HSPA8 [extracellular region]

HSPA8 [secretory granule lumen]

HSPA6 [secretory granule lumen]

HSPA2 [nucleoplasm]

HSPA1L [nucleoplasm]

HSPA1A [nucleoplasm]

HSPA6 [nucleoplasm]

HSPA13 [nucleoplasm]

HSPA7 [nucleoplasm]

HSPA1L [cytosol]

HSPA2 [cytosol]

HSPA13 [cytosol]

HSPA6 [cytosol]

HSPA7 [cytosol]

HSPA1A [cytosol]

Me3K561-HSPA8 [nucleoplasm]

Inferred From

HSPA8 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_010052.1

PRO

P11484

PDB

3GL1

Interactors (55)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07260	1	EIF4E [cytosol] (R-SCE-72578)	0.643	3
UniProt:P08018	10	phospho-p-S271,T275-MAP2K7 [cytosol] (R-SCE-450353) MAP2K7 [cytosol] (R-SCE-450276) MAP2K6 [cytosol] (R-SCE-167998) MAP2K3 [cytosol] (R-SCE-168051) phospho-p-S207,T211-MAP2K6 [cytosol] (R-SCE-206255) phospho-p-S189,T193-MAP2K3 [cytosol] (R-SCE-167955) phospho-p-S207,T211-MAP2K6 [nucleoplasm] (R-SCE-450258) phospho-p-S189,T193-MAP2K3 [nucleoplasm] (R-SCE-450229) phospho-p-S257,T261-MAP2K4 [cytosol] (R-SCE-168170) MAP2K4 [cytosol] (R-SCE-168107)	0.643	3
UniProt:P29469 MCM2	2	MCM2 [nucleoplasm] (R-SCE-68557) yMcm2 [nucleoplasm] (R-SCE-169497)	0.564	2
UniProt:P02829	11	HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [cytosol] (R-SCE-192864)	0.564	3
UniProt:Q03834	1	MSH6 [nucleoplasm] (R-SCE-5357528)	0.527	3
UniProt:P29547	1	EEF1G [cytosol] (R-SCE-156925)	0.527	3
UniProt:P38217	1	TNPO1 [cytosol] (R-SCE-180743)	0.527	2
UniProt:P15303	4	SEC23A [endoplasmic reticulum membrane] (R-SCE-203976) phospho-p-S742,T747 SEC23A [cytosol] (R-SCE-5685740) SEC23A [cytosol] (R-SCE-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-SCE-204024)	0.527	2
UniProt:P32775	1	GBE1 [cytosol] (R-SCE-71576)	0.527	3
UniProt:Q03529	1	FA2H [endoplasmic reticulum membrane] (R-SCE-5693771)	0.527	2
UniProt:P36017	5	GGC-RAB5A [early endosome membrane] (R-SCE-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-SCE-8871125) GGC-RAB5A [cytosol] (R-SCE-8870432) RAB5A [endosome membrane] (R-SCE-452257) RAB5A [cytosol] (R-SCE-2201187)	0.527	3
UniProt:P53599	7	K48polyUb-NIK [cytosol] (R-SCE-5668525) phospho-p-T559-MAP3K14 [cytosol] (R-SCE-5668531) phospho-p-MAP3K14 [cytosol] (R-SCE-168187) phospho-p-S400-MAP3K8 [cytosol] (R-SCE-389738-2) MAP3K14 [cytosol] (R-SCE-168189) MAP3K8 [cytosol] (R-SCE-389388-2) phospho-p-S400,T290-MAP3K8 [cytosol] (R-SCE-5684259-2)	0.527	2
UniProt:P43565	1	phospho-p-T194,T207,T741-MASTL [nucleoplasm] (R-SCE-2430549)	0.527	3
UniProt:Q99247	1	WDR48 [nucleoplasm] (R-SCE-419549)	0.527	2
UniProt:Q03957	3	CDK13 [ficolin-1-rich granule lumen] (R-SCE-6801374) CDK13 [extracellular region] (R-SCE-6806442) CDK13 [nucleoplasm] (R-SCE-6797014)	0.527	2
UniProt:P54861	2	DNM1L [cytosol] (R-SCE-351943) DNM1L [mitochondrial outer membrane] (R-SCE-351942)	0.527	3
UniProt:Q08647 PUS7	1	PUS7 [nucleoplasm] (R-SCE-6786522)	0.527	2
UniProt:P06786	4	TOP2B [nucleoplasm] (R-SCE-4641359) SUMO1-K-TOP2B [nucleoplasm] (R-SCE-4641297) SUMO1-K-TOP2A [nucleoplasm] (R-SCE-4641367) TOP2A [nucleoplasm] (R-SCE-1362276)	0.527	3
UniProt:P02309	14	AcK5,12-HIST1H4A [nucleoplasm] (R-SCE-212078) SUMO1-HIST1H4 [nucleoplasm] (R-SCE-4570518) AcK13-HIST1H4 [nucleoplasm] (R-SCE-4568744) AcK6-HIST1H4 [nucleoplasm] (R-SCE-4568748) AcK17-HIST1H4 [nucleoplasm] (R-SCE-427469) AcK9-HIST1H4 [nucleoplasm] (R-SCE-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-SCE-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-SCE-4754243) MeR4-HIST1H4 [nucleoplasm] (R-SCE-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-SCE-5651656) AcK-HIST1H4 [nucleoplasm] (R-SCE-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-SCE-5651652) HIST1H4 [nucleoplasm] (R-SCE-181902) MeK-HIST1H4A [nucleoplasm] (R-SCE-2172676)	0.527	3
UniProt:P00546	5	CDK2 [nucleoplasm] (R-SCE-68365) phospho-p-T160-CDK2 [nucleoplasm] (R-SCE-187967) phospho-p-Y15-CDK2 [nucleoplasm] (R-SCE-187905) CDK2 [cytosol] (R-SCE-157440) phospho-p-CDK2 [nucleoplasm] (R-SCE-68370)	0.527	3
UniProt:P22147 XRN1	2	XRN1 [cytosol] (R-SCE-429835) XRN1_YEAST [cytosol] (R-SCE-429980)	0.527	2
UniProt:P24783	4	DDX17 [nucleoplasm] (R-SCE-3900090) SUMO1-K50-DDX17 [nucleoplasm] (R-SCE-3900104) SUMO1-K53-DDX5 [nucleoplasm] (R-SCE-3900041) DDX5 [nucleoplasm] (R-SCE-3900136)	0.527	3
UniProt:P39108	2	PEX7 [cytosol] (R-SCE-9033107) PEX7 [peroxisomal membrane] (R-SCE-9033493)	0.527	2
UniProt:P54837	7	phospho-MyrG-p-S16-TICAM2 [secretory granule membrane] (R-SCE-6804964) phospho-MyrG-p-S16-TICAM2 [plasma membrane] (R-SCE-166160) TMED10 [Golgi membrane] (R-SCE-6808801) TMED10 [transport vesicle] (R-SCE-6808802) TMED10 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-SCE-5689845) TMED10 [endoplasmic reticulum membrane] (R-SCE-5689479) phospho-MyrG-p-S16-TICAM2 [endosome membrane] (R-SCE-2201336)	0.527	2
UniProt:P40344	2	ATG3 [cytosol] (R-SCE-5671860) CysO263-ATG3 [cytosol] (R-SCE-5683569)	0.527	2
UniProt:P46962	3	CCNK [nucleoplasm] (R-SCE-6796619) CCNT2 [nucleoplasm] (R-SCE-51613) CCNT1 [nucleoplasm] (R-SCE-51611)	0.527	3
UniProt:P25454	2	phospho-p-T309-RAD51 [nucleoplasm] (R-SCE-5685231) RAD51 [nucleoplasm] (R-SCE-62637)	0.527	2
UniProt:P48365	2	TBC1D25 [autophagosome] (R-SCE-8854607) TBC1D15 [cytosol] (R-SCE-8854150)	0.527	2
UniProt:P38205 NCL1	1	NCL1 [nucleoplasm] (R-SCE-6790210)	0.527	2
UniProt:P39935	2	EIF4G1 [cytosol] (R-SCE-72584) phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-SCE-165762)	0.527	2
UniProt:P06778	3	phospho-p-Y104-RAD52 [nucleoplasm] (R-SCE-5686588) SUMO1-K411,K412,K414-RAD52 [nucleoplasm] (R-SCE-4568909) RAD52 [nucleoplasm] (R-SCE-62639)	0.527	3
UniProt:Q06245	1	EXOC5 [cytosol] (R-SCE-265045)	0.527	2
UniProt:P06700	1	SIRT1 [nucleoplasm] (R-SCE-427531)	0.527	2
UniProt:Q01477	3	USP37 [nucleoplasm] (R-SCE-5697000) USP10 [nucleoplasm] (R-SCE-3222218) USP10 [cytosol] (R-SCE-6782974)	0.527	2
UniProt:Q03497	4	PAK3 [cytosol] (R-SCE-428457-2) phospho-p-S154,T436-PAK3 [cytosol] (R-SCE-5357471-2) PAK1 [cytosol] (R-SCE-162629) phospho-p-S144,T423-PAK1 [cytosol] (R-SCE-399819)	0.527	3
UniProt:P25847	1	MSH2 [nucleoplasm] (R-SCE-5357525)	0.527	2
UniProt:P54839	2	HMGCS2 [mitochondrial matrix] (R-SCE-56573) HMGCS1 [cytosol] (R-SCE-191329)	0.527	2
UniProt:P53550	1	DCP2 [cytosol] (R-SCE-429937)	0.527	3
UniProt:Q08972	1	ABCF1 [cytosol] (R-SCE-5216139)	0.527	3
UniProt:P10823	10	N-(C14:0)-GNAT1 [photoreceptor disc membrane] (R-SCE-2534062) GNAT1 [cytosol] (R-SCE-2565915) GNAT1 (Met removed) [cytosol] (R-SCE-2534043) GNAL [plasma membrane] (R-SCE-170657) GNAT1 [plasma membrane] (R-SCE-167411) GNAI3 [plasma membrane] (R-SCE-55365) GNA14 [plasma membrane] (R-SCE-167453) GNA15 [plasma membrane] (R-SCE-167450) GNA11 [plasma membrane] (R-SCE-167446) GNAI2 [plasma membrane] (R-SCE-55435)	0.527	2
UniProt:P28817	1	HIBCH [mitochondrial matrix] (R-SCE-70872)	0.527	2
UniProt:P04819	1	LIG1 [nucleoplasm] (R-SCE-53787)	0.527	2
UniProt:P29496 MCM5	2	MCM5 [nucleoplasm] (R-SCE-68551) yMcm5 [nucleoplasm] (R-SCE-169511)	0.527	3
UniProt:Q00955	6	ACACA [cytosol] (R-SCE-1660609) phospho-Btn-p-S79-ACACB [mitochondrial outer membrane] (R-SCE-8876892-2) Btn-ACACA [cytosol] (R-SCE-2976730) ACACB [mitochondrial outer membrane] (R-SCE-4167505-2) Btn-ACACB [mitochondrial outer membrane] (R-SCE-2993858-2) ACACB [cytosol] (R-SCE-52493-2)	0.527	2
UniProt:Q08920	2	NCBP2 [cytosol] (R-SCE-162458) NCBP2 [nucleoplasm] (R-SCE-51463)	0.527	2
UniProt:P43558	1	YOD1 [cytosol] (R-SCE-6781909)	0.527	2
UniProt:P02994	6	EEF1A1 [ficolin-1-rich granule lumen] (R-SCE-6801528) EEF1A1 [cytosol] (R-SCE-156905) EEF1A1 [extracellular region] (R-SCE-6806456) EEF1A1 [secretory granule lumen] (R-SCE-6801479) Me3K318-EEF1A1 [cytosol] (R-SCE-8932419) Me3K79-EEF1A1 [cytosol] (R-SCE-8932212)	0.527	3
UniProt:P32457	3	SEPT4 [cytosol] (R-SCE-6805825) SEPT7 [cytosol] (R-SCE-5692671) SEPT4 [mitochondrial outer membrane] (R-SCE-6805816)	0.527	2
UniProt:P39009	2	phospho-p-T68-CHEK2 [nucleoplasm] (R-SCE-113825) phospho-p-S,3T-CHEK2 [nucleoplasm] (R-SCE-5683784)	0.527	2
UniProt:P38615	1	GSK3B [cytosol] (R-SCE-2997551)	0.527	2
UniProt:P38859 DNA2	2	DNA2 [nucleoplasm] (R-SCE-68465) apo-DNA2 [cytosol] (R-SCE-2564783)	0.527	3
UniProt:P54784	4	phospho-PolyUb,p-S,T-ORC1 [cytosol] (R-SCE-9032195) phospho-p-S,T-ORC1 [nucleoplasm] (R-SCE-68943) phospho-PolyUb,p-S,T-ORC1 [nucleoplasm] (R-SCE-9032189) ORC1 [nucleoplasm] (R-SCE-68522)	0.527	2
UniProt:P53858	2	PHACTR2 [platelet alpha granule membrane] (R-SCE-8848893) PHACTR2 [plasma membrane] (R-SCE-8848883)	0.527	2
UniProt:P53730	1	ALG12 [endoplasmic reticulum membrane] (R-SCE-449348)	0.527	2
UniProt:Q04958	1	PNPLA6 [endoplasmic reticulum membrane] (R-SCE-1498821)	0.527	2