Reactome | MeK-HIST1H4A [nucleoplasm]

MeK-HIST1H4A [nucleoplasm]

Stable Identifier

R-SCE-2172676

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

P02309

Locations in the PathwayBrowser

Expand all

Cell Cycle (Saccharomyces cerevisiae)

- Cell Cycle, Mitotic (Saccharomyces cerevisiae)
  - M Phase (Saccharomyces cerevisiae)
    - Mitotic Prophase (Saccharomyces cerevisiae)
      - Condensation of Prophase Chromosomes (Saccharomyces cerevisiae)
        
        PHF8 demethylates histone H4K20me1 (Saccharomyces cerevisiae)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MeK-HIST1H4A [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P02309

Reference Genes

BioGPS Gene:852294

BioGPS Gene:855701

ENSEMBL:YBR009C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YBR009C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YNL030W

Monarch:852294

Monarch:855701

NCBI Gene:852294

NCBI Gene:855701

SGD:YBR009C

Reference Transcript

Other Identifiers

1E6I

1ID3

1Q1A

1SZC

1SZD

2DVQ

2DVR

2E3K

2FSB

2H2H

2L5A

2QQF

2QQG

3TO6

4932.YNL030W

4JJN

4KUD

4PSX

4TWI

4TWJ

5W0V

AAA34660.1

AAT92979.1

CAA25311.1

CAA25313.1

CAA84947.1

CAA95892.1

DAA07130.1

DAA10515.1

EntrezGene:852294

EntrezGene:855701

GO:0000786

GO:0000788

GO:0003674

GO:0003677

GO:0005575

GO:0005634

GO:0005694

GO:0006325

GO:0006333

GO:0006334

GO:0006366

GO:0008150

GO:0008213

GO:0016570

GO:0018193

GO:0031298

GO:0034729

GO:0042393

GO:0043934

GO:0043935

GO:0046982

GO:0051321

GO:0061587

IPR001951

IPR009072

IPR019809

IPR035425

NM_001178357.1

NM_001182869.1

NP_009563.1

NP_014368.1

PF15511

PR00623

SM00417

UPI000004F8D3

YBR009C

YBR009C_mRNA

YNL030W

YNL030W_mRNA

Participant Of

input

PHF8 demethylates MeK21-histone H4

hasComponent

Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm]

Other forms of this molecule

SUMO1-HIST1H4 [nucleoplasm]

AcK5,12-HIST1H4A [nucleoplasm]

AcK13-HIST1H4 [nucleoplasm]

AcK6-HIST1H4 [nucleoplasm]

AcK17-HIST1H4 [nucleoplasm]

AcK9-HIST1H4 [nucleoplasm]

Me2aR4-HIST1H4 [nucleoplasm]

Me2sR4-HIST1H4 [nucleoplasm]

MeR4-HIST1H4 [nucleoplasm]

Me3K21-HIST1H4 [nucleoplasm]

AcK-HIST1H4 [nucleoplasm]

Me2K21-HIST1H4 [nucleoplasm]

HIST1H4 [nucleoplasm]

Inferred From

MeK-HIST1H4A [nucleoplasm] (Homo sapiens)

MeK21-HIST1H4 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6-methyl-L-lysine at 21 (in Homo sapiens)

Coordinate

PsiMod Name

N6-methyl-L-lysine [MOD:00085]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine.

Cross References

RefSeq

NP_009563.1, NP_014368.1

PRO

P02309

PDB

1SZD, 5ZBA, 2L5A, 6GEJ, 4KUD, 1SZC, 2QQF, 1E6I, 2QQG, 2FSB, 6GEN, 5ZBB, 2H2H, 5W0V, 4TWJ, 4PSX, 3TO6, 4TWI, 2DVR, 4JJN, 2E3K, 1Q1A, 1ID3, 6QLD, 2DVQ

Interactors (64)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61830	13	2xAcK-HIST2H3A [nucleoplasm] (R-SCE-427525-2) MeK-HIST2H3A [nucleoplasm] (R-SCE-417240-2) AcK24-HIST2H3A [nucleoplasm] (R-SCE-4568747-2) AcK19-HIST2H3A [nucleoplasm] (R-SCE-4568750-2) AcK15-HIST2H3A [nucleoplasm] (R-SCE-4568755-2) AcK5-HIST2H3A [nucleoplasm] (R-SCE-4568752-2) Me3K-10-HIST2H3A [nucleoplasm] (R-SCE-427744-2) AcK10-H3F3A [nucleoplasm] (R-SCE-5250654) Ack10-HIST2H3A [nucleoplasm] (R-SCE-4568924-2) Me2K-10-HIST2H3A [nucleoplasm] (R-SCE-427407-2) Me2K5-H3F3A [nucleoplasm] (R-SCE-1214206) Me3K-28-HIST2H3A [nucleoplasm] (R-SCE-212253-2) HIST2H3A [nucleoplasm] (R-SCE-212281-2)	0.912	69
UniProt:P04912 H2A2			0.793	18
UniProt:Q12373 HIF1			0.752	23
UniProt:P32447	1	ASF1A [nucleoplasm] (R-SCE-417169)	0.752	18
UniProt:Q12161 PSH1			0.744	17
UniProt:Q06205 FKBP4			0.678	5
UniProt:P02309	14	AcK5,12-HIST1H4A [nucleoplasm] (R-SCE-212078) SUMO1-HIST1H4 [nucleoplasm] (R-SCE-4570518) AcK13-HIST1H4 [nucleoplasm] (R-SCE-4568744) AcK6-HIST1H4 [nucleoplasm] (R-SCE-4568748) AcK17-HIST1H4 [nucleoplasm] (R-SCE-427469) AcK9-HIST1H4 [nucleoplasm] (R-SCE-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-SCE-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-SCE-4754243) MeR4-HIST1H4 [nucleoplasm] (R-SCE-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-SCE-5651656) AcK-HIST1H4 [nucleoplasm] (R-SCE-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-SCE-5651652) HIST1H4 [nucleoplasm] (R-SCE-181902) MeK-HIST1H4A [nucleoplasm] (R-SCE-2172676)	0.678	7
UniProt:P32597	1	SMARCA2 [nucleoplasm] (R-SCE-389256-2)	0.677	4
UniProt:P11746 MCM1			0.669	3
UniProt:P02293	15	HIST1H2BA [nucleoplasm] (R-SCE-181916) HIST1H2BK [nucleoplasm] (R-SCE-181898) AcK6-HIST1H2BB [nucleoplasm] (R-SCE-4568637) AcK16-HIST1H2BB [nucleoplasm] (R-SCE-4568639) AcK13-HIST1H2BB [nucleoplasm] (R-SCE-4568629) AcK21-HIST1H2BB [nucleoplasm] (R-SCE-4568632) AcK16-HIST2H2BE [nucleoplasm] (R-SCE-4568660) AcK22-HIST1H2BA [nucleoplasm] (R-SCE-4568647) AcK17-HIST1H2BA [nucleoplasm] (R-SCE-4568631) AcK14-HIST1H2BA [nucleoplasm] (R-SCE-4568615) AcK7-HIST1H2BA [nucleoplasm] (R-SCE-4568624) AcK-HIST1H2BB [nucleoplasm] (R-SCE-4549272) AcK-HIST1H2BA [nucleoplasm] (R-SCE-4549263) Ub-HIST1H2BB [nucleoplasm] (R-SCE-6782554) Ub-HIST1H2BA [nucleoplasm] (R-SCE-6782561)	0.669	3
UniProt:P40161 RT106			0.669	8
UniProt:P15790 CKA1	1	CKA1 [nucleoplasm] (R-SCE-6790643)	0.669	3
UniProt:P39984	1	RBBP7 [nucleoplasm] (R-SCE-212227-2)	0.669	15
UniProt:Q12341	1	HAT1 [nucleoplasm] (R-SCE-3662337)	0.669	27
UniProt:Q04636	1	SSRP1 [nucleoplasm] (R-SCE-65105)	0.669	10
UniProt:P32558	1	SUPT16H [nucleoplasm] (R-SCE-112415)	0.669	16
UniProt:Q08649	1	KAT5 [nucleoplasm] (R-SCE-3321979)	0.667	5
UniProt:Q02486	6	HMGB1 [secretory granule lumen] (R-SCE-6803337-4) HC23,45-HMGB1 [extracellular region] (R-SCE-6797422-4) HMGB1 [ficolin-1-rich granule lumen] (R-SCE-6803291-4) HMGB1 [nucleoplasm] (R-SCE-266221-4) HMGB2 [nucleoplasm] (R-SCE-266211-4) HMGB1 [extracellular region] (R-SCE-879382-4)	0.628	8
UniProt:Q00362	2	PPP2R2A [nucleoplasm] (R-SCE-1564978) PPP2R2A [cytosol] (R-SCE-377253)	0.592	4
UniProt:P38890 SET5			0.59	3
UniProt:P47050	1	CUL4B [nucleoplasm] (R-SCE-975973)	0.589	2
UniProt:Q03973	6	HMGB1 [secretory granule lumen] (R-SCE-6803337-6) HC23,45-HMGB1 [extracellular region] (R-SCE-6797422-6) HMGB1 [ficolin-1-rich granule lumen] (R-SCE-6803291-6) HMGB1 [nucleoplasm] (R-SCE-266221-6) HMGB2 [nucleoplasm] (R-SCE-266211-6) HMGB1 [extracellular region] (R-SCE-879382-6)	0.564	3
UniProt:P02294	15	Ub-HIST1H2BB [nucleoplasm] (R-SCE-6782554-2) Ub-HIST1H2BA [nucleoplasm] (R-SCE-6782561-2) AcK-HIST1H2BA [nucleoplasm] (R-SCE-4549263-2) AcK-HIST1H2BB [nucleoplasm] (R-SCE-4549272-2) AcK7-HIST1H2BA [nucleoplasm] (R-SCE-4568624-2) AcK14-HIST1H2BA [nucleoplasm] (R-SCE-4568615-2) AcK17-HIST1H2BA [nucleoplasm] (R-SCE-4568631-2) AcK22-HIST1H2BA [nucleoplasm] (R-SCE-4568647-2) AcK16-HIST2H2BE [nucleoplasm] (R-SCE-4568660-2) AcK21-HIST1H2BB [nucleoplasm] (R-SCE-4568632-2) AcK13-HIST1H2BB [nucleoplasm] (R-SCE-4568629-2) AcK16-HIST1H2BB [nucleoplasm] (R-SCE-4568639-2) AcK6-HIST1H2BB [nucleoplasm] (R-SCE-4568637-2) HIST1H2BA [nucleoplasm] (R-SCE-181916-2) HIST1H2BK [nucleoplasm] (R-SCE-181898-2)	0.564	8
UniProt:P32833	1	ORC2 [nucleoplasm] (R-SCE-68405)	0.564	2
UniProt:P36124 SET3			0.564	2
UniProt:P38826 ORC6			0.564	2
UniProt:Q12510 CMR1			0.564	2
UniProt:P54784	4	phospho-PolyUb,p-S,T-ORC1 [cytosol] (R-SCE-9032195) phospho-p-S,T-ORC1 [nucleoplasm] (R-SCE-68943) phospho-PolyUb,p-S,T-ORC1 [nucleoplasm] (R-SCE-9032189) ORC1 [nucleoplasm] (R-SCE-68522)	0.564	2
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.556	3
UniProt:P32333 MOT1			0.527	2
UniProt:P31244 RAD16			0.527	3
UniProt:P33748 MSN2			0.527	2
UniProt:Q06488	1	PBRM1 [nucleoplasm] (R-SCE-389254)	0.527	2
UniProt:P32657 CHD1			0.527	2
UniProt:Q04199 CAC2			0.527	3
UniProt:P53741 BRE5			0.527	2
UniProt:P43639 CKB1	1	CKB1 [nucleoplasm] (R-SCE-6790659)	0.527	2
UniProt:Q03940	1	RUVBL1 [nucleoplasm] (R-SCE-418323)	0.527	2
UniProt:P43596 IOC3			0.527	2
UniProt:Q12692	2	H2AFZ [nucleoplasm] (R-SCE-181897) H2AFV [nucleoplasm] (R-SCE-8862427)	0.527	4
UniProt:P05317	1	RPLP0 [cytosol] (R-SCE-72396)	0.527	3
UniProt:P53091 MCM6	2	MCM6 [nucleoplasm] (R-SCE-68553) yMcm6 [nucleoplasm] (R-SCE-169504)	0.527	2
UniProt:P43609	1	SMARCC1 [nucleoplasm] (R-SCE-389257-2)	0.527	2
UniProt:P34218 SAS3			0.527	3
UniProt:P11938 RAP1			0.527	3
UniProt:P46677	2	TAF1 [nucleoplasm] (R-SCE-65539) TAF1L [nucleoplasm] (R-SCE-212435)	0.527	2
UniProt:Q12464 RUVB2			0.527	2
UniProt:P38144 ISW1			0.527	2
UniProt:P32481 GCD11	2	EIF2S3 [cytosol] (R-SCE-72514) GCD11 [cytosol] (R-SCE-9633596)	0.527	2
UniProt:P14832	7	PPIA [secretory granule lumen] (R-SCE-6801400) PPIE [secretory granule lumen] (R-SCE-6801369) PPIE [extracellular region] (R-SCE-6806493) PPIE [ficolin-1-rich granule lumen] (R-SCE-6801393) PPIA [ficolin-1-rich granule lumen] (R-SCE-6801391) PPIA [extracellular region] (R-SCE-173646) PPIE [nucleoplasm] (R-SCE-6781959)	0.527	2
UniProt:P40069 IMB4			0.527	3
UniProt:P10592	23	HSPA8 [nucleoplasm] (R-SCE-5082380-3) HSPA8 [cytosol] (R-SCE-264476-3) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-3) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-3) HSPA1A [extracellular region] (R-SCE-6805872-3) HSPA6 [extracellular region] (R-SCE-6806500-3) HSPA8 [extracellular region] (R-SCE-6805936-3) HSPA8 [secretory granule lumen] (R-SCE-6801530-3) HSPA6 [secretory granule lumen] (R-SCE-6801472-3) HSPA2 [nucleoplasm] (R-SCE-912480-3) HSPA1L [nucleoplasm] (R-SCE-5082367-3) HSPA1A [nucleoplasm] (R-SCE-6792605-3) HSPA6 [nucleoplasm] (R-SCE-5252088-3) HSPA13 [nucleoplasm] (R-SCE-5252009-3) HSPA7 [nucleoplasm] (R-SCE-5252047-3) HSPA1L [cytosol] (R-SCE-3371410-3) HSPA2 [cytosol] (R-SCE-3371408-3) HSPA13 [cytosol] (R-SCE-5251981-3) HSPA6 [cytosol] (R-SCE-3371521-3) HSPA7 [cytosol] (R-SCE-5251954-3) HSPA1A [cytosol] (R-SCE-6792602-3) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-3)	0.527	3
UniProt:Q06639 RSC3			0.527	4
UniProt:P11484	23	HSPA8 [nucleoplasm] (R-SCE-5082380-4) HSPA8 [cytosol] (R-SCE-264476-4) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-4) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-4) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-4) HSPA1A [extracellular region] (R-SCE-6805872-4) HSPA6 [extracellular region] (R-SCE-6806500-4) HSPA8 [extracellular region] (R-SCE-6805936-4) HSPA8 [secretory granule lumen] (R-SCE-6801530-4) HSPA6 [secretory granule lumen] (R-SCE-6801472-4) HSPA2 [nucleoplasm] (R-SCE-912480-4) HSPA1L [nucleoplasm] (R-SCE-5082367-4) HSPA1A [nucleoplasm] (R-SCE-6792605-4) HSPA6 [nucleoplasm] (R-SCE-5252088-4) HSPA13 [nucleoplasm] (R-SCE-5252009-4) HSPA7 [nucleoplasm] (R-SCE-5252047-4) HSPA1L [cytosol] (R-SCE-3371410-4) HSPA2 [cytosol] (R-SCE-3371408-4) HSPA13 [cytosol] (R-SCE-5251981-4) HSPA6 [cytosol] (R-SCE-3371521-4) HSPA7 [cytosol] (R-SCE-5251954-4) HSPA1A [cytosol] (R-SCE-6792602-4) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-4)	0.527	3
UniProt:Q04779 RCO1			0.527	2
UniProt:Q03761	1	TAF12 [nucleoplasm] (R-SCE-65555)	0.527	2
UniProt:P43572 EPL1			0.527	2
UniProt:P22579	3	SIN3A [nucleoplasm] (R-SCE-351657) SUMO1-SIN3A [nucleoplasm] (R-SCE-4086071) SIN3B-1 [nucleoplasm] (R-SCE-349685)	0.527	2
UniProt:Q12432 EAF3			0.527	2
UniProt:Q01477	3	USP37 [nucleoplasm] (R-SCE-5697000) USP10 [nucleoplasm] (R-SCE-3222218) USP10 [cytosol] (R-SCE-6782974)	0.527	2
UniProt:P29496 MCM5	2	MCM5 [nucleoplasm] (R-SCE-68551) yMcm5 [nucleoplasm] (R-SCE-169511)	0.527	3
UniProt:P36012	12	2xAcK-HIST2H3A [nucleoplasm] (R-SCE-427525) MeK-HIST2H3A [nucleoplasm] (R-SCE-417240) AcK24-HIST2H3A [nucleoplasm] (R-SCE-4568747) AcK19-HIST2H3A [nucleoplasm] (R-SCE-4568750) AcK15-HIST2H3A [nucleoplasm] (R-SCE-4568755) AcK5-HIST2H3A [nucleoplasm] (R-SCE-4568752) Me3K-10-HIST2H3A [nucleoplasm] (R-SCE-427744) Ack10-HIST2H3A [nucleoplasm] (R-SCE-4568924) Me2K-10-HIST2H3A [nucleoplasm] (R-SCE-427407) HIST2H3A [nucleoplasm] (R-SCE-212281) Me3K-28-HIST2H3A [nucleoplasm] (R-SCE-212253) Me2K5-HIST2H3A [nucleoplasm] (R-SCE-1214225)	0.524	2
UniProt:Q05123	4	POTEKP [extracellular region] (R-SCE-350725) ACTG1 [lysosomal membrane] (R-SCE-196169) ACTB(1-375) [cytosol] (R-SCE-201861) ACTB(1-375) [plasma membrane] (R-SCE-196016)	0.508	2
UniProt:P37898	5	ERAP1 [endoplasmic reticulum lumen] (R-SCE-947609-2) LNPEP [cytosol] (R-SCE-983098-2) ERAP2 [endoplasmic reticulum lumen] (R-SCE-983097-2) ANPEP [plasma membrane] (R-SCE-2022340-2) ANPEP [secretory granule membrane] (R-SCE-6806152-2)	0.508	2