Reactome | BUB3 [cytosol]

BUB3 [cytosol]

Stable Identifier

R-SCE-141416

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

BUB3, P26449

Locations in the PathwayBrowser

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Cell Cycle (Saccharomyces cerevisiae)

- Cell Cycle Checkpoints (Saccharomyces cerevisiae)
  - Mitotic Spindle Checkpoint (Saccharomyces cerevisiae)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Saccharomyces cerevisiae)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Saccharomyces cerevisiae)
        
        Formation of the MCC complex (Saccharomyces cerevisiae)
        
        BUB3 [cytosol] (Saccharomyces cerevisiae)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Saccharomyces cerevisiae)
        
        BUB3 [cytosol] (Saccharomyces cerevisiae)
- Cell Cycle, Mitotic (Saccharomyces cerevisiae)
  - Regulation of mitotic cell cycle (Saccharomyces cerevisiae)
    - APC/C-mediated degradation of cell cycle proteins (Saccharomyces cerevisiae)
      - Regulation of APC/C activators between G1/S and early anaphase (Saccharomyces cerevisiae)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Saccharomyces cerevisiae)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Saccharomyces cerevisiae)
        
        Formation of the MCC complex (Saccharomyces cerevisiae)
        
        BUB3 [cytosol] (Saccharomyces cerevisiae)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Saccharomyces cerevisiae)
        
        BUB3 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P26449

Gene Names

BUB3

Reference Genes

BioGPS Gene:854191 BUB3

ENSEMBL:YOR026W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YOR026W BUB3

Monarch:854191 BUB3

NCBI Gene:854191 BUB3

SGD:YOR026W

Reference Transcript

RefSeq:NM_001183445.1 BUB3

Other Identifiers

1776539_at

854191

8544_at

GO:0000278

GO:0000776

GO:0000778

GO:0003674

GO:0005515

GO:0005575

GO:0005634

GO:0005654

GO:0005694

GO:0007049

GO:0007059

GO:0007094

GO:0008150

GO:0023052

GO:0031399

GO:0032182

GO:0033043

GO:0033597

GO:0043130

GO:0044774

GO:0048285

GO:0051726

GO:0070647

GO:1902499

GO:1990298

Participates

as an input of

Formation of the MCC complex (Saccharomyces cerevisiae)

as a component of

hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Saccharomyces cerevisiae)

Inferred From

BUB3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_014669.1

OpenTargets

ENSG00000154473

PRO

P26449

PDB

1YFQ, 4BL0, 2I3S, 2I3T, 1U4C

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41695	1	BUB1B [cytosol] (R-SCE-141436)	0.946	12
UniProt:P47074 MAD3			0.931	14
UniProt:P40957	1	MAD1 [cytosol] (R-SCE-141433)	0.677	4
UniProt:P26309	2	CDC20 [nucleoplasm] (R-SCE-174112) CDC20 [cytosol] (R-SCE-141412)	0.641	8
UniProt:P40958	1	MAD2 [cytosol] (R-SCE-141447)	0.641	4

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