Reactome | Plcg2 [cytosol]

Plcg2 [cytosol]

Stable Identifier

R-RNO-984806

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

PLCG2, P24135

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
      - BTK binds BTK inhibitors (Rattus norvegicus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
        
        PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        BTK:BTK inhibitors [plasma membrane] (Rattus norvegicus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
        
        PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
        
        PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - p-DAPP1 (p-BAM32) binds PLCG2 (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - C-type lectin receptors (CLRs) (Rattus norvegicus)
    - Dectin-2 family (Rattus norvegicus)
      - SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
  - DAP12 interactions (Rattus norvegicus)
    - DAP12 signaling (Rattus norvegicus)
      - Activation of RAC1 by VAV2/3 (Rattus norvegicus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Phosphorylation of BTK by p-SYK (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-SYK/p-BTK [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
  - Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
    - FCERI mediated Ca+2 mobilization (Rattus norvegicus)
      - Autophosphorylation of BTK/ITK (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
    - FCERI mediated MAPK activation (Rattus norvegicus)
      - Activation of RAC1 by VAV (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Autophosphorylation of PAK (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Phosphorylation and activation of VAV (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Recruitment of PAK to the membrane by binding active RAC1 (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Recruitment of VAV to p-SLP-76 (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
    - Role of phospholipids in phagocytosis (Rattus norvegicus)
      - Phosphorylation and activation of PLCG (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
      - Recruitment of PLCgamma to membrane (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Rattus norvegicus)
        
        PLC gamma1,2 [cytosol] (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)
  - Toll-like Receptor Cascades (Rattus norvegicus)
    - Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
      - Endocytosis of TLR4:LY96:LPS:CD14 (Rattus norvegicus)
        
        Plcg2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P24135 Plcg2

Gene Names

Plcg2

Chain

chain:1-1265

Reference Genes

BioGPS Gene:29337 Plcg2

KEGG Gene (Rattus norvegicus):29337 Plcg2

Monarch:29337 Plcg2

NCBI Gene:29337 Plcg2

UCSC:P24135 Plcg2

Reference Transcript

RefSeq:NM_017168.1 Plcg2

Participates

as a component of

as an input of

as a member of

PLC gamma1,2 [cytosol] (Rattus norvegicus)

This entity regulates

Positively

Endocytosis of TLR4:LY96:LPS:CD14 (Rattus norvegicus)

Other forms of this molecule

phospho-Plcg2 [cytosol]

phospho-Plcg2 [plasma membrane]

p-Y753,Y759,Y1197,Y1217-Plcg2 [plasma membrane]

phospho-Plcg2 [plasma membrane]

Plcg2 [plasma membrane]

phospho-Plcg2 [plasma membrane]

Inferred From

PLCG2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_058864.1

PRO

P24135

RGD

3348

PDB

2EOB

Cite Us!