Calmodulin-activated adenylate cyclases Adcy1 and Adcy8 generate cAMP

Stable Identifier
R-RNO-9617504
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Calmodulin-activated adenylate cyclases Adcy1 and Adcy8 generate cAMP
In rat neurons, Ca2+ influx through NMDA receptors in the post-synaptic neuron results in activation of adenylate cyclase (Chetkovich et al. 1991), which is mediated by binding of activated calmodulin (Calm1:4xCa2+) to adenyalte cyclase (Chetkovich and Sweatt 1993). Based on studies in mice, two adenylate cyclase isoforms, Adcy1 (AC1) and Adcy8 (AC8), are activated by calmodulin and involved in NMDA receptor-mediated long term potentiation (LTP) (Wong et al. 1999, Wei et al. 2002).
Literature References
Participants
Input
Output
Catalyst Activity

calcium- and calmodulin-responsive adenylate cyclase activity of (Adcy1,Adcy8):Calm1:4xCa2+ [plasma membrane]

Physical Entity
(Adcy1,Adcy8):Calm1:4xCa2+ [plasma membrane] (Rattus norvegicus)
Activity
calcium- and calmodulin-responsive adenylate cyclase activity (GO:0008294)
Orthologous Events
Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-08-27)
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