Rasgrf1 oligomers bind GluN1:GluN2B (Grin1:Grin2b) di-heterotetramers

Stable Identifier
R-RNO-9617436
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Rasgrf1 oligomers bind GluN1:GluN2B (Grin1:Grin2b) di-heterotetramers

Based on studies in rat neurons, binding of Rasgrf1 to the NMDA receptor subunit Glun2B (Grin2b) is necessary for NMDA receptor-mediated activation of Ras signaling through Rasgrf1 (Krapivinsky et al. 2003).

Literature References
PubMed ID Title Journal Year
14622581 The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1

Krapivinsky, G, Krapivinsky, L, Manasian, Y, Ivanov, A, Tyzio, R, Pellegrino, C, Ben-Ari, Y, Clapham, DE, Medina, I

Neuron 2003
Participants
Orthologous Events
Authored
Reviewed
Created