GluN3A (Grin3a), GluN3B (Grin3b) NMDA receptors traffic to the plasma membrane

Stable Identifier
R-RNO-9610782
Type
Reaction [BlackBoxEvent]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
GluN3A (Grin3a), GluN3B (Grin3b) NMDA receptors traffic to the plasma membrane

In rat neurons, NMDA receptors that contain GluN3A (Grin3a) or GluN3B (Grin3b) subunits, traffic to the plasma membrane to the perisynaptic regions, located at the periphery of the postsynaptic density (PSD). GluN3a and GluN3b do not have PDZ-binding domains and thus do not interact directly with PSD-95 family members. A small fraction of GluN3-containing NMDA receptors that localize to the central region of the PSD may be tri-heteromers with GluN2 subunits (Perez-Otano et al. 2006, Wee et al. 2016).

Literature References
PubMed ID Title Journal Year
26700428 Ontogenic Profile and Synaptic Distribution of GluN3 Proteins in the Rat Brain and Hippocampal Neurons

Wee, KS, Tan, FC, Cheong, YP, Khanna, S, Low, CM

Neurochem. Res. 2016
16617342 Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1

Pérez-Otaño, I, Luján, R, Tavalin, SJ, Plomann, M, Modregger, J, Liu, XB, Jones, EG, Heinemann, SF, Lo, DC, Ehlers, MD

Nat. Neurosci. 2006
Participants
Orthologous Events
Authored
Reviewed
Created