Reactome | phospho-Cbl [cytosol]

phospho-Cbl [cytosol]

Stable Identifier

R-RNO-8875457

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

p-Y-CBL, A0A8I6G3R2

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by MET (Rattus norvegicus)
    - Negative regulation of MET activity (Rattus norvegicus)
      - CBL monoubiquitinates activated MET (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        p-Y-CBL:GRB2 [cytosol] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Rattus norvegicus)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        p-Y-CBL:GRB2 [cytosol] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        p-Y-CBL:GRB2 [cytosol] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        p-Y-CBL:GRB2 [cytosol] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
      - EPS15 and HGS bind ubiquitinated MET (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        p-Y-CBL:GRB2 [cytosol] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        p-Y-CBL:GRB2 [cytosol] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
      - MET phosphorylates CBL (Rattus norvegicus)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Rattus norvegicus)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        p-Y-CBL:GRB2 [cytosol] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Rattus norvegicus)
        
        phospho-Cbl [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A8I6G3R2

Gene Names

Cbl

Reference Genes

ENSEMBL:ENSRNOG00000008444

ENSEMBL:ENSRNOG00000008444.8 Cbl

Reference Transcript

Other Identifiers

10916669

1379603_at

1380069_at

17851655

500985

5745570

5754160

5781549

5792349

5854693

5866567

5987519

5997178

6028351

6032770

6116936

6123006

6146275

6276154

6284360

6381871

6449529

6516931

6545637

6710864

A_64_P009325

GE1111203

GO:0001784

GO:0003824

GO:0004842

GO:0005509

GO:0005515

GO:0005794

GO:0005829

GO:0005886

GO:0005929

GO:0006511

GO:0007166

GO:0012501

GO:0016192

GO:0016567

GO:0016600

GO:0016740

GO:0017124

GO:0023051

GO:0023052

GO:0030163

GO:0032487

GO:0036211

GO:0042059

GO:0043066

GO:0043226

GO:0046875

GO:0048260

GO:0051897

GO:0061630

GO:0070086

GO:0140096

GO:2000583

ILMN_1355687

PH_rn_0001767

PH_rn_0021361

Participates

as a component of

Other forms of this molecule

phospho-Cbl [cytosol]

phospho-Cbl [plasma membrane]

phospho-Cbl [cytosol]

Cbl [cytosol]

Inferred From

p-Y-CBL [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_576396.3, XP_001066453.2

Ensembl

ENSRNOP00000079790, ENSRNOT00000101607, ENSRNOG00000008444

RGD

1561386

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