Reactome | GNAS1 [plasma membrane]

GNAS1 [plasma membrane]

Stable Identifier

R-RNO-8873940

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

Q63803

Locations in the PathwayBrowser

Expand all

Metabolism (Rattus norvegicus)

- Integration of energy metabolism (Rattus norvegicus)
  - Regulation of insulin secretion (Rattus norvegicus)
    - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Rattus norvegicus)
      - GLP1R binds GLP1 (Rattus norvegicus)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Rattus norvegicus)
        
        G alpha (s):GDP [plasma membrane] (Rattus norvegicus)
        
        GNAS [plasma membrane] (Rattus norvegicus)
        
        GNAS1 [plasma membrane] (Rattus norvegicus)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Rattus norvegicus)
        
        G alpha (s):GDP [plasma membrane] (Rattus norvegicus)
        
        GNAS [plasma membrane] (Rattus norvegicus)
        
        GNAS1 [plasma membrane] (Rattus norvegicus)
      - GLP1R binds GLP1R agonists (Rattus norvegicus)
        
        GLP1R:GLP1R agonists [plasma membrane] (Rattus norvegicus)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Rattus norvegicus)
        
        G alpha (s):GDP [plasma membrane] (Rattus norvegicus)
        
        GNAS [plasma membrane] (Rattus norvegicus)
        
        GNAS1 [plasma membrane] (Rattus norvegicus)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Rattus norvegicus)
        
        G alpha (s):GDP [plasma membrane] (Rattus norvegicus)
        
        GNAS [plasma membrane] (Rattus norvegicus)
        
        GNAS1 [plasma membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class B/2 (Secretin family receptors) (Rattus norvegicus)
      - Glucagon-type ligand receptors (Rattus norvegicus)
        
        GLP1R binds GLP1 (Rattus norvegicus)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Rattus norvegicus)
        
        G alpha (s):GDP [plasma membrane] (Rattus norvegicus)
        
        GNAS [plasma membrane] (Rattus norvegicus)
        
        GNAS1 [plasma membrane] (Rattus norvegicus)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Rattus norvegicus)
        
        G alpha (s):GDP [plasma membrane] (Rattus norvegicus)
        
        GNAS [plasma membrane] (Rattus norvegicus)
        
        GNAS1 [plasma membrane] (Rattus norvegicus)

Transport of small molecules (Rattus norvegicus)

- Aquaporin-mediated transport (Rattus norvegicus)
  - Vasopressin regulates renal water homeostasis via Aquaporins (Rattus norvegicus)
    - AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Rattus norvegicus)
      - AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Rattus norvegicus)
        
        G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Rattus norvegicus)
        
        G alpha (s):GDP [plasma membrane] (Rattus norvegicus)
        
        GNAS [plasma membrane] (Rattus norvegicus)
        
        GNAS1 [plasma membrane] (Rattus norvegicus)
      - AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Rattus norvegicus)
        
        G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Rattus norvegicus)
        
        G alpha (s):GTP [plasma membrane] (Rattus norvegicus)
        
        GNAS [plasma membrane] (Rattus norvegicus)
        
        GNAS1 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q63803

Reference Genes

ENSEMBL:ENSRNOG00000025889

ENSEMBL:ENSRNOG00000047374

ENSEMBL:ENSRNOG00055001007

ENSEMBL:ENSRNOG00055001386

ENSEMBL:ENSRNOG00060001165

ENSEMBL:ENSRNOG00065013234

Participates

as a candidate of

GNAS [plasma membrane] (Rattus norvegicus)

Inferred From

GNAS1 [plasma membrane] (Homo sapiens)

Cross References

RGD

2716

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