Reactome | Scarb2 [plasma membrane]

Scarb2 [plasma membrane]

Stable Identifier

R-RNO-8864566

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

SCARB2, P27615

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - AP-2 directly binds some endocytic cargo (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Scarb2 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P27615

Gene Names

Scarb2

Reference Genes

BioGPS Gene:117106 Scarb2

ENSEMBL:ENSRNOG00000002225

ENSEMBL:ENSRNOG00000002225.7 Scarb2

ENSEMBL:ENSRNOG00055006490

ENSEMBL:ENSRNOG00060018619

ENSEMBL:ENSRNOG00065017922

KEGG Gene (Rattus norvegicus):117106 Scarb2

Monarch:117106 Scarb2

NCBI Gene:117106 Scarb2

UCSC:P27615 Scarb2

Reference Transcript

RefSeq:NM_054001.2 Scarb2

Other Identifiers

10771622

117106

1368379_at

17688673

5697396

5743465

5811450

5882327

5892417

5936977

5946523

6001721

6208732

6268622

6270011

6436878

6535223

6562331

6566028

6643111

6705170

A_44_P533959

D10587_at

D10587_g_at

GE1252587

GO:0005044

GO:0005764

GO:0005773

GO:0016020

GO:0038024

GO:0043226

ILMN_1361889

PH_rn_0005212

Participates

as a member of

AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Scarb2 [clathrin-coated endocytic vesicle membrane]

Inferred From

SCARB2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_446453.1

Ensembl

ENSRNOT00000103647, ENSRNOG00000002225, ENSRNOP00000097524

PRO

P27615

RGD

621882

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