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Socs3 [cytosol]
Stable Identifier
R-RNO-873794
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
SOCS3, O88583
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Polyubiquitination of substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Interferon alpha/beta signaling (Rattus norvegicus)
Activation of JAK kinases (Rattus norvegicus)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Interferon gamma signaling (Rattus norvegicus)
Regulation of IFNG signaling (Rattus norvegicus)
SOCS-1 and SOCS-3 binds to p-JAK2 (Rattus norvegicus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Transphosphorylation of JAK1 (Rattus norvegicus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Signaling by CSF3 (G-CSF) (Rattus norvegicus)
Inactivation of CSF3 (G-CSF) signaling (Rattus norvegicus)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Rattus norvegicus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-6 family signaling (Rattus norvegicus)
Interleukin-6 signaling (Rattus norvegicus)
SOCS3 binds IL6ST (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Neddylation (Rattus norvegicus)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
NEDD8-CRL5 E3 ligase [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
NEDD8-CRL5 E3 ligase [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Non-Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by PTK6 (Rattus norvegicus)
PTK6 Activates STAT3 (Rattus norvegicus)
SOCS3 binds activated PTK6 (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
p-Y342-PTK6:SOCS3 [cytosol] (Rattus norvegicus)
Socs3 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O88583
Gene Names
Socs3
Reference Genes
BioGPS Gene:89829 Socs3
ENSEMBL:ENSRNOG00000002946
ENSEMBL:ENSRNOG00000063373
KEGG Gene (Rattus norvegicus):89829 Socs3
Monarch:89829 Socs3
NCBI Gene:89829 Socs3
UCSC:O88583 Socs3
Reference Transcript
RefSeq:NM_053565.1 Socs3
Participates
as a member of
CUL5-box protein [cytosol] (Rattus norvegicus)
SOCS-1 and SOCS-3 [cytosol] (Rattus norvegicus)
as an input of
SOCS3 binds IL6ST (Rattus norvegicus)
SOCS3 binds activated PTK6 (Rattus norvegicus)
as a component of
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Rattus norvegicus)
p-Y342-PTK6:SOCS3 [cytosol] (Rattus norvegicus)
Inferred From
SOCS3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_446017.1
PRO
O88583
RGD
621087
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