Reactome | Rpl10 [cytosol]

Rpl10 [cytosol]

Stable Identifier

R-RNO-72402

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

RPL10, Q6PDV7

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Rattus norvegicus)

- Nonsense-Mediated Decay (NMD) (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Rattus norvegicus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL10,RPL10L [cytosol] (Rattus norvegicus)
        
        Rpl10 [cytosol] (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL10,RPL10L [cytosol] (Rattus norvegicus)
        
        Rpl10 [cytosol] (Rattus norvegicus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL10,RPL10L [cytosol] (Rattus norvegicus)
        
        Rpl10 [cytosol] (Rattus norvegicus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL10,RPL10L [cytosol] (Rattus norvegicus)
        
        Rpl10 [cytosol] (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL10,RPL10L [cytosol] (Rattus norvegicus)
        
        Rpl10 [cytosol] (Rattus norvegicus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL10,RPL10L [cytosol] (Rattus norvegicus)
        
        Rpl10 [cytosol] (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL10,RPL10L [cytosol] (Rattus norvegicus)
        
        Rpl10 [cytosol] (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Rattus norvegicus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL10,RPL10L [cytosol] (Rattus norvegicus)
        
        Rpl10 [cytosol] (Rattus norvegicus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL10,RPL10L [cytosol] (Rattus norvegicus)
        
        Rpl10 [cytosol] (Rattus norvegicus)
- rRNA processing (Rattus norvegicus)
  - rRNA processing in the nucleus and cytosol (Rattus norvegicus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Rattus norvegicus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL10,RPL10L [cytosol] (Rattus norvegicus)
        
        Rpl10 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q6PDV7

Gene Names

Rpl10

Reference Genes

BioGPS Gene:81764 Rpl10

ENSEMBL:ENSRNOG00000056765

ENSEMBL:ENSRNOG00000056765.2 Rpl10

ENSEMBL:ENSRNOG00055025288

ENSEMBL:ENSRNOG00060006707

ENSEMBL:ENSRNOG00065014999

KEGG Gene (Rattus norvegicus):81764 Rpl10

Monarch:81764 Rpl10

NCBI Gene:81764 Rpl10

Reference Transcript

RefSeq:NM_031100.1 Rpl10

Other Identifiers

10940406

1367625_at

17880082

5689825

5806085

6020698

6040206

6054787

6228290

6256447

6285157

6312420

6318473

6603611

6658452

6679044

6689203

81764

A_42_P552949

A_64_P010456

A_64_P072064

GE21165

GO:0003735

GO:0005198

GO:0005737

GO:0005783

GO:0005790

GO:0005829

GO:0005840

GO:0006412

GO:0022625

GO:0043226

GO:0045202

ILMN_1376415

PH_rn_0022168

rc_AA945611_at

Participates

as a member of

RPL10,RPL10L [cytosol] (Rattus norvegicus)

Inferred From

RPL10 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_112362.1

Ensembl

ENSRNOT00000083951, ENSRNOG00000056765, ENSRNOP00000070105

PRO

Q6PDV7

RGD

621178

PDB

7QGG

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