Reactome | NDUFS2 [mitochondrial matrix]

NDUFS2 [mitochondrial matrix]

Stable Identifier

R-RNO-6788520

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

mitochondrial matrix

Synonyms

Q641Y2

Locations in the PathwayBrowser

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Metabolism (Rattus norvegicus)

- Aerobic respiration and respiratory electron transport (Rattus norvegicus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Rattus norvegicus)
    - Respiratory electron transport (Rattus norvegicus)
      - Complex I biogenesis (Rattus norvegicus)
        
        IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        NDUF subunits bind to form the IP subcomplex (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        NUBPL transfers 4Fe-4S to Complex I subunits (Rattus norvegicus)
        
        NDUF subunits [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        NDUF:4Fe-4S subunits [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        980kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Rattus norvegicus)
        
        980kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        IP subcomplex [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
        
        Complex I [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Rattus norvegicus)
        
        Complex I [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)
        
        NDUFS2 [mitochondrial matrix] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q641Y2

Reference Genes

BioGPS Gene:289218

ENSEMBL:ENSRNOG00000038372

ENSEMBL:ENSRNOG00000038372.5

ENSEMBL:ENSRNOG00055022093

ENSEMBL:ENSRNOG00060025952

KEGG Gene (Rattus norvegicus):289218

Monarch:289218

NCBI Gene:289218

UCSC:Q641Y2

Reference Transcript

Other Identifiers

10769830

1371482_at

17686599

289218

5843548

6033254

6047697

6153393

6237225

6262740

6294503

6400231

6486601

6649875

6682104

A_44_P255359

GE1108207

GE18040

GO:0003824

GO:0003954

GO:0005215

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0006979

GO:0007005

GO:0008137

GO:0016491

GO:0016651

GO:0019826

GO:0022008

GO:0030154

GO:0031625

GO:0032981

GO:0042063

GO:0042775

GO:0043226

GO:0048038

GO:0048856

GO:0051287

GO:0061351

GO:0065003

GO:0071453

GO:0140299

PH_rn_0015387

rc_AI170770_at

Participates

as a member of

NDUF subunits [mitochondrial matrix] (Rattus norvegicus)

as a component of

NDUFS2:4Fe-4S [mitochondrial matrix] (Rattus norvegicus)

Inferred From

NDUFS2 [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

NP_001011907.1, XP_003751325.1

Ensembl

ENSRNOG00000038372, ENSRNOT00000058423, ENSRNOP00000055224

PRO

Q641Y2

RGD

1307109

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