Reactome | TNFSF10 [extracellular region]

TNFSF10 [extracellular region]

Stable Identifier

R-RNO-66186

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

extracellular region

Synonyms

A0A0U5J7B5

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Rattus norvegicus)

- Apoptosis (Rattus norvegicus)
  - Caspase activation via extrinsic apoptotic signalling pathway (Rattus norvegicus)
    - Caspase activation via Death Receptors in the presence of ligand (Rattus norvegicus)
      - Dimerization of procaspase-8 (Rattus norvegicus)
        
        TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFSF10 [extracellular region] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFSF10 [extracellular region] (Rattus norvegicus)
      - Regulation by c-FLIP (Rattus norvegicus)
        
        Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFSF10 [extracellular region] (Rattus norvegicus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFSF10 [extracellular region] (Rattus norvegicus)
        
        FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFSF10 [extracellular region] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFSF10 [extracellular region] (Rattus norvegicus)
- Regulated Necrosis (Rattus norvegicus)
  - RIPK1-mediated regulated necrosis (Rattus norvegicus)
    - Regulation of necroptotic cell death (Rattus norvegicus)
      - CASP8 activity is inhibited (Rattus norvegicus)
        
        FLIP(L) and procaspase-8 form heterodimer (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFSF10 [extracellular region] (Rattus norvegicus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFSF10 [extracellular region] (Rattus norvegicus)
        
        FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFSF10 [extracellular region] (Rattus norvegicus)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFSF10 [extracellular region] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0U5J7B5

Reference Genes

ENSEMBL:ENSRNOG00000013269

ENSEMBL:ENSRNOG00000067968

ENSEMBL:ENSRNOG00000067968.1

Other Identifiers

10814528

17737479

246775

6039044

6051240

6189038

6267287

6299595

6393397

GE1138194

GO:0002376

GO:0005164

GO:0005515

GO:0006955

GO:0007005

GO:0008270

GO:0012501

GO:0016020

GO:0023052

GO:0032813

GO:0042802

GO:0043065

GO:0043123

GO:0045569

GO:0090200

GO:2001238

ILMN_1362036

PH_rn_0009337

Participates

as an input of

TRAIL binds TRAIL receptors (Rattus norvegicus)

as a component of

TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)

Inferred From

TNFSF10 [extracellular region] (Homo sapiens)

Cross References

Ensembl

ENSRNOG00000067968, ENSRNOT00000119330, ENSRNOP00000076967

RGD

628734

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