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TCEA1 [nucleoplasm]
Stable Identifier
R-RNO-65748
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
Q4KLL0
Locations in the PathwayBrowser
Expand all
DNA Repair (Rattus norvegicus)
Nucleotide Excision Repair (Rattus norvegicus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Rattus norvegicus)
Dual incision in TC-NER (Rattus norvegicus)
3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)
TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Rattus norvegicus)
TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
ERCC5 and RPA bind TC-NER site (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Formation of TC-NER Pre-Incision Complex (Rattus norvegicus)
Assembly of the pre-incision complex in TC-NER (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Rattus norvegicus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
TP53 Regulates Transcription of DNA Repair Genes (Rattus norvegicus)
CCNK:CDK12 binds RNA Pol II at DNA repair genes (Rattus norvegicus)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Rattus norvegicus)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Rattus norvegicus)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Rattus norvegicus)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Rattus norvegicus)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
RNA Polymerase II Pre-transcription Events (Rattus norvegicus)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Rattus norvegicus)
Paused processive elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Abortive termination of elongation after arrest (Rattus norvegicus)
Aborted elongation complex after arrest [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Elongating transcript encounters a lesion in the template (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Resumption of elongation after recovery from pausing (Rattus norvegicus)
Paused processive elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TFIIS-mediated recovery of elongation from arrest (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
RNA Polymerase II Transcription Elongation (Rattus norvegicus)
Addition of nucleotides leads to transcript elongation (Rattus norvegicus)
Elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Formation of RNA Pol II elongation complex (Rattus norvegicus)
Recruitment of elongation factors to form elongation complex (Rattus norvegicus)
Elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Pol II elongation complex moves on the template as transcript elongates (Rattus norvegicus)
Elongation complex prior to separation [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Separation of elongating transcript from template (Rattus norvegicus)
Elongation complex prior to separation [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Rattus norvegicus)
TCEA1 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q4KLL0
Reference Genes
BioGPS Gene:362479
ENSEMBL:ENSRNOG00000005869
ENSEMBL:ENSRNOG00000005869.5
ENSEMBL:ENSRNOG00000022323
ENSEMBL:ENSRNOG00000022323.6
ENSEMBL:ENSRNOG00055013145
ENSEMBL:ENSRNOG00055017690
ENSEMBL:ENSRNOG00060009641
ENSEMBL:ENSRNOG00065018368
KEGG Gene (Rattus norvegicus):362479
KEGG Gene (Rattus norvegicus):498453
Monarch:362479
NCBI Gene:362479
UCSC:Q4KLL0
Reference Transcript
RefSeq:XM_006251720.3
RefSeq:XM_003752784.4
RefSeq:XM_006237816.3
RefSeq:NM_001025735.1
Other Identifiers
10700760
10779353
10875233
1367485_at
1382861_at
1394724_at
17697484
17805564
362479
5718853
5742995
5746987
5840773
6217389
6217792
6241203
6259356
6407760
6418579
6424384
6429455
6430420
6522606
6638537
6659566
6683103
6729913
6741052
A_43_P10591
A_64_P084028
A_64_P146124
GE1218736
GO:0003676
GO:0005634
GO:0006351
GO:0006368
GO:0008270
GO:0043226
ILMN_1359903
ILMN_1369147
ILMN_1371058
PH_rn_0014121
rc_AA997486_at
rc_AI146090_at
Participates
as an output of
Elongating transcript encounters a lesion in the template (Rattus norvegicus)
as a component of
Aborted elongation complex after arrest [nucleoplasm] (Rattus norvegicus)
Paused processive elongation complex [nucleoplasm] (Rattus norvegicus)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Rattus norvegicus)
Elongation complex prior to separation [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
Elongation complex [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Rattus norvegicus)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Rattus norvegicus)
as an input of
Recruitment of elongation factors to form elongation complex (Rattus norvegicus)
Assembly of the pre-incision complex in TC-NER (Rattus norvegicus)
Inferred From
TCEA1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_003752832.1
,
XP_006237878.1
,
XP_006251782.1
,
NP_001020906.1
Ensembl
ENSRNOP00000097722
,
ENSRNOG00000022323
,
ENSRNOT00000007696
,
ENSRNOP00000084958
,
ENSRNOG00000005869
,
ENSRNOT00000104892
PRO
Q4KLL0
RGD
1309880
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