Reactome | Sh2d2a [cytosol]

Sh2d2a [cytosol]

Stable Identifier

R-RNO-4420125

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

SH2D2A, Q5I0Q2

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by VEGF (Rattus norvegicus)
    - VEGFA-VEGFR2 Pathway (Rattus norvegicus)
      - AXL autophosphorylates on Y779 and Y821 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
      - AXL binds SRC-1 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
      - Phosphorylation of SRC-1 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
      - SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
      - VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
      - p-6Y-VEGFR2 binds SH2D2A (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
      - p-AXL binds PI3K (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        Sh2d2a [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q5I0Q2

Gene Names

Sh2d2a

Reference Genes

BioGPS Gene:310688 Sh2d2a

ENSEMBL:ENSRNOG00000013294

ENSEMBL:ENSRNOG00000013294.8 Sh2d2a

KEGG Gene (Rattus norvegicus):310688 Sh2d2a

Monarch:310688 Sh2d2a

NCBI Gene:310688 Sh2d2a

Reference Transcript

RefSeq:NM_207605.3 Sh2d2a

Other Identifiers

10816378

1393830_at

17739667

310688

5646110

5779993

5785216

5844137

5898148

5930563

5948835

6095191

6191078

6245779

6340447

6426685

6494138

6531671

6560341

6610669

6703613

GE1203844

GO:0002376

GO:0042098

ILMN_1370566

PH_rn_0006951

rc_AA956603_at

Participates

as an input of

p-6Y-VEGFR2 binds SH2D2A (Rattus norvegicus)

as a component of

VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)

Inferred From

SH2D2A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_997488.2

Ensembl

ENSRNOT00000017798, ENSRNOP00000017798, ENSRNOG00000013294

RGD

1303076

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