Reactome | GRM7 [plasma membrane]

GRM7 [plasma membrane]

Stable Identifier

R-RNO-420536

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

P35400

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (i) signalling events (Rattus norvegicus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM7 [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM7 [plasma membrane] (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Rattus norvegicus)
      - Metabotropic glutamate receptors bind glutamate (Rattus norvegicus)
        
        GRM1-8 [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM7 [plasma membrane] (Rattus norvegicus)
        
        GRM1-8:L-Glu [plasma membrane] (Rattus norvegicus)
        
        GRM1-8 [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM7 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P35400

Reference Genes

BioGPS Gene:81672

ENSEMBL:ENSRNOG00000005662

ENSEMBL:ENSRNOG00000005662.7

ENSEMBL:ENSRNOG00055007981

ENSEMBL:ENSRNOG00060014101

ENSEMBL:ENSRNOG00065012289

KEGG Gene (Rattus norvegicus):81672

Monarch:81672

NCBI Gene:81672

Reference Transcript

RefSeq:NM_031040.1

Other Identifiers

10857643

1369781_at

17785885

5638590

5671203

5881130

5916196

6025952

6045148

6212786

6215130

6401026

6426321

6457224

6495973

6603696

6691880

81672

A_43_P12487

D16817_at

D16817_g_at

GO:0004930

GO:0005886

GO:0007154

GO:0007165

GO:0007186

GO:0016020

GO:0023052

GO:0060089

ILMN_1376436

PH_rn_0012046

PH_rn_0019770

PH_rn_0023365

Participates

as a member of

GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)

Inferred From

GRM7 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_112302.1

ZINC - Substances

GRM7_RAT

ZINC target

P35400

Ensembl

ENSRNOP00000053411, ENSRNOG00000005662, ENSRNOT00000056570

PRO

P35400

ZINC - Predictions - Purchasable

GRM7_RAT

RGD

619857

PDB

2E4Z

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9EP80 Pick1	3	PICK1 [endocytic vesicle membrane] (R-RNO-417017) Pick1 [plasma membrane] (R-RNO-8858476) PICK1 [plasma membrane] (R-RNO-416989)	0.737	9
UniProt:P63088 Ppp1cc	2	Serine/threonine protein phosphatase PP1-gamma catalytic subunit [cytosol] (R-RNO-163463) PPP1CC [cytosol] (R-RNO-163443)	0.508	4