Reactome | GRM2 [plasma membrane]

GRM2 [plasma membrane]

Stable Identifier

R-RNO-420468

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

P31421

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (i) signalling events (Rattus norvegicus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM2 [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM2 [plasma membrane] (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Rattus norvegicus)
      - Metabotropic glutamate receptors bind glutamate (Rattus norvegicus)
        
        GRM1-8 [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM2 [plasma membrane] (Rattus norvegicus)
        
        GRM1-8:L-Glu [plasma membrane] (Rattus norvegicus)
        
        GRM1-8 [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM2 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P31421

Reference Genes

BioGPS Gene:24415

ENSEMBL:ENSRNOG00000013171

ENSEMBL:ENSRNOG00000013171.4

ENSEMBL:ENSRNOG00055011818

ENSEMBL:ENSRNOG00060017564

ENSEMBL:ENSRNOG00065008268

KEGG Gene (Rattus norvegicus):24415

Monarch:24415

NCBI Gene:24415

UCSC:P31421

Reference Transcript

Other Identifiers

10919953

1370998_at

17855400

24415

5639324

5722213

5760065

5761200

5845833

5902053

5932226

6097381

6125022

6400911

6471088

6580541

6624656

6631065

6662327

A_43_P15751

GE21866

GO:0001641

GO:0004930

GO:0005246

GO:0007186

GO:0010467

GO:0016020

GO:0023052

GO:0043005

GO:0060089

GO:0060292

GO:0090461

GO:0098772

GO:0098978

GO:0099171

ILMN_1356100

M92075_at

PH_rn_0005151

Participates

as a member of

GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)

Inferred From

GRM2 [plasma membrane] (Homo sapiens)

Cross References

ZINC - Investigational

GRM2_RAT

RefSeq

XP_017450945.1, NP_001099181.1, XP_017450946.1

ZINC - Metabolites

GRM2_RAT

ZINC - World Drugs

GRM2_RAT

ZINC - FDA approved

GRM2_RAT

ZINC - Substances

GRM2_RAT

ZINC - Biogenic

GRM2_RAT

Ensembl

ENSRNOP00000017607, ENSRNOG00000013171, ENSRNOT00000017607

ZINC target

P31421

PRO

P31421

RGD

2743

ZINC - Predictions - Purchasable

GRM2_RAT

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96S59 RANBP9	1	RANBP9 [cytosol] (R-HSA-374586)	0.508	4