Reactome | GRIN2C [plasma membrane]

GRIN2C [plasma membrane]

Stable Identifier

R-RNO-419560

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

Q00961

Locations in the PathwayBrowser

Expand all

Neuronal System (Rattus norvegicus)

- Protein-protein interactions at synapses (Rattus norvegicus)
  - Synaptic adhesion-like molecules (Rattus norvegicus)
    - PSD-95 binds NMDA receptor (Rattus norvegicus)
      - NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2C [plasma membrane] (Rattus norvegicus)
      - NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2C [plasma membrane] (Rattus norvegicus)
    - SALM1 binds NMDA receptor (Rattus norvegicus)
      - NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2C [plasma membrane] (Rattus norvegicus)
      - SALM1:NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2C [plasma membrane] (Rattus norvegicus)
    - SALM2 associate with AMPA and NMDA receptors (Rattus norvegicus)
      - AMPA, NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2C [plasma membrane] (Rattus norvegicus)
      - SALM2:AMPA, NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        AMPA, NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2C [plasma membrane] (Rattus norvegicus)
- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - Activation of NMDA receptors and postsynaptic events (Rattus norvegicus)
      - Assembly and cell surface presentation of NMDA receptors (Rattus norvegicus)
        
        GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Rattus norvegicus)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2A:GRIN2C tri-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        GRIN2C [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2C di-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        GRIN2C [plasma membrane] (Rattus norvegicus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Rattus norvegicus)
        
        Ca2+ influx into the post-synaptic cell (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2A:GRIN2C tri-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        GRIN2C [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2C di-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        GRIN2C [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q00961 Grin2c

Gene Names

Grin2c

Chain

signal peptide:1-19, chain:20-1237

Reference Genes

BioGPS Gene:24411 Grin2c

KEGG Gene (Rattus norvegicus):24411 Grin2c

Monarch:24411 Grin2c

NCBI Gene:24411 Grin2c

Reference Transcript

Participates

as a member of

NR2 subunits [plasma membrane] (Rattus norvegicus)

as a component of

Other forms of this molecule

Grin2c [endoplasmic reticulum membrane]

GRIN2C [endoplasmic reticulum membrane]

p-Y-Grin2c [plasma membrane]

Grin2c [plasma membrane]

Inferred From

GRIN2C [plasma membrane] (Homo sapiens)

Cross References

ZINC - Investigational

NMDE3_RAT

RefSeq

XP_006247769.1, XP_017452479.1, XP_017452481.1, NP_036707.3, XP_017452477.1, XP_006247771.1, XP_017452480.1, XP_017452476.1, XP_017452478.1, XP_017452475.1

ZINC - World Drugs

NMDE3_RAT

ZINC - FDA approved

NMDE3_RAT

ZINC - Substances

NMDE3_RAT

ZINC - Biogenic

NMDE3_RAT

ZINC target

Q00961

PRO

Q00961

RGD

2739

ZINC - Predictions - Purchasable

NMDE3_RAT

PDB

8HDK, 7YFI, 7YFG, 7YFH

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O88382 MAGI2			0.553	2
UniProt:P31016 Dlg4	3	Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [plasma membrane] (R-RNO-9612601)	0.553	2
UniProt:Q63ZW7 INADL			0.508	2