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Glycogen synthase kinase-3 beta [cytosol]
Stable Identifier
R-RNO-198619
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
KG3B_RAT, Gsk3b
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to heat stress (Rattus norvegicus)
Regulation of HSF1-mediated heat shock response (Rattus norvegicus)
Constitutive phosphorylation by GSK3 (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Developmental Biology (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
Semaphorin interactions (Rattus norvegicus)
CRMPs in Sema3A signaling (Rattus norvegicus)
Phosphorylation of CRMPs by GSK3beta (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Hedgehog (Rattus norvegicus)
Hedgehog 'off' state (Rattus norvegicus)
GLI3 is processed to GLI3R by the proteasome (Rattus norvegicus)
GSK3 phosphorylates p-GLI3 (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
Degradation of beta-catenin by the destruction complex (Rattus norvegicus)
AXIN is phosphorylated in the destruction complex (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Association of beta-catenin with the destruction complex (Rattus norvegicus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Beta-catenin phosphorylation cascade (Rattus norvegicus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Rattus norvegicus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Rattus norvegicus)
FRAT1,2:GSK3beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Rattus norvegicus)
FRAT1,2:GSK3beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Rattus norvegicus)
FRAT1,2:GSK3beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Degradation of ubiquitinated beta catenin by the proteasome (Rattus norvegicus)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Phosphorylation of APC component of the destruction complex (Rattus norvegicus)
CK1alpha (GSK3) [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
TCF dependent signaling in response to WNT (Rattus norvegicus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Rattus norvegicus)
Beta-catenin is released from the destruction complex (Rattus norvegicus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
FRAT proteins bind GSK3beta (Rattus norvegicus)
FRAT1,2:GSK3beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Rattus norvegicus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [early endosome membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P18266 Gsk3b
Gene Names
Gsk3b
Chain
chain:1-420
Reference Genes
BioGPS Gene:84027 Gsk3b
KEGG Gene (Rattus norvegicus):84027 Gsk3b
Monarch:84027 Gsk3b
NCBI Gene:84027 Gsk3b
UCSC:P18266 Gsk3b
Reference Transcript
RefSeq:NM_032080.1 Gsk3b
Participant Of
hasComponent
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
FRAT1,2:GSK3beta [cytosol]
GSK3B:AXIN1 [cytosol]
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
hasCandidate
CK1alpha (GSK3) [cytosol]
input
FRAT proteins bind GSK3beta
hasMember
GSK3 [cytosol]
Other forms of this molecule
Phospho-GSK3b [cytosol]
GSK3B [nucleoplasm]
Inferred From
GSK3B [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_114469.1
IntEnz
2.7.11.1
ZINC - Substances
GSK3B_RAT
ZINC target
P18266
PRO
P18266
ZINC - Predictions - Purchasable
GSK3B_RAT
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