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PTPN6 [cytosol]
Stable Identifier
R-RNO-197938
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P81718
Locations in the PathwayBrowser
Expand all
Hemostasis (Rattus norvegicus)
Cell surface interactions at the vascular wall (Rattus norvegicus)
PECAM1 interactions (Rattus norvegicus)
Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)
PECAM-1:SHP-1 complex [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
G6B binds PTPN6,PTPN11 (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
SYK autophosphorylates (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Platelet homeostasis (Rattus norvegicus)
Platelet sensitization by LDL (Rattus norvegicus)
Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)
PECAM-1:SHP-1 complex [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Costimulation by the CD28 family (Rattus norvegicus)
PD-1 signaling (Rattus norvegicus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
SHP-1 and SHP-2 bind pBTLA (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
SYK autophosphorylates at the activated BCR (Rattus norvegicus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
CD22 mediated BCR regulation (Rattus norvegicus)
SHP1 binds p-CD22 (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Interferon alpha/beta signaling (Rattus norvegicus)
Regulation of IFNA/IFNB signaling (Rattus norvegicus)
Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Interferon gamma signaling (Rattus norvegicus)
Transphosphorylation of JAK1 (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-2 family signaling (Rattus norvegicus)
Interleukin receptor SHC signaling (Rattus norvegicus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
Interleukin receptor SHC signaling (Rattus norvegicus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
PTPN6 dephosphorylates JAK3 (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Signaling by SCF-KIT (Rattus norvegicus)
Regulation of KIT signaling (Rattus norvegicus)
Interaction of SHP1 and KIT (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P81718
Reference Genes
BioGPS Gene:116689
ENSEMBL:ENSRNOG00000014294
KEGG Gene (Rattus norvegicus):116689
Monarch:116689
NCBI Gene:116689
UCSC:P81718
Reference Transcript
RefSeq:NM_053908.1
Participates
as a component of
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
PTPN6:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
PECAM-1:SHP-1 complex [plasma membrane] (Rattus norvegicus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Rattus norvegicus)
as an input of
SHP1 binds p-CD22 (Rattus norvegicus)
Interaction of SHP1 and KIT (Rattus norvegicus)
Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)
as a member of
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
This entity regulates
Negatively
Transphosphorylation of JAK1
(Rattus norvegicus)
Other forms of this molecule
PTPN6 [tertiary granule lumen]
PTPN6 [extracellular region]
PTPN6 [specific granule lumen]
Inferred From
PTPN6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_446360.1
PRO
P81718
RGD
620660
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