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About
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beta-NGF [extracellular region]
Stable Identifier
R-RNO-181840
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Death Receptor Signalling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NADE modulates death signalling (Rattus norvegicus)
14-3-3epsilon attentuates NADE-related apoptosis (Rattus norvegicus)
NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
p75NTR binds to NADE (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
p75NTR:NADE promotes caspase2/3 activation (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
NRIF signals cell death from the nucleus (Rattus norvegicus)
TRAF6 binds to p75NTR:NRIF (Rattus norvegicus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
NFG and proNGF binds to p75NTR (Rattus norvegicus)
NGF homodimer binds to p75NTR (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
p75NTR regulates axonogenesis (Rattus norvegicus)
Axonal growth stimulation (Rattus norvegicus)
NGF binding to p75NTR inactivates RHOA (Rattus norvegicus)
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
p75NTR signals via NF-kB (Rattus norvegicus)
NF-kB is activated and signals survival (Rattus norvegicus)
IKKbeta is activated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
p75NTR recruits signalling complexes (Rattus norvegicus)
IKK-beta is recruited (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
IRAK interacts with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
MYD88 dissociates (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
TRAF6 is auto-ubiquitinated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
p62 recruits an atypical PKC (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
p75NTR interacts with RIP2 (Rattus norvegicus)
NGF:p75NTR:RIP2 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Expression and Processing of Neurotrophins (Rattus norvegicus)
NGF processing (Rattus norvegicus)
Pro-beta-NGF and mature beta-NGF are secreted (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
Activation of TRKA receptors (Rattus norvegicus)
TRKA activation by NGF (Rattus norvegicus)
Activated TrkA receptor internalizes to endosomes (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
The bound receptor dimerizes (Rattus norvegicus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
beta-NGF dimer:TrkA receptor dimer [plasma membrane] (Rattus norvegicus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
beta-NGF dimer binds to TrkA receptor (Rattus norvegicus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
PI3K/AKT activation (Rattus norvegicus)
Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
Retrograde neurotrophin signalling (Rattus norvegicus)
Axonal transport of NGF:Trk complexes (Rattus norvegicus)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
Signalling to ERKs (Rattus norvegicus)
Prolonged ERK activation events (Rattus norvegicus)
ARMS-mediated activation (Rattus norvegicus)
ARMS is phosphorylated by active TrkA receptor (Rattus norvegicus)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
C3G stimulates nucleotide exchange on Rap1 (Rattus norvegicus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
Crk's SH3 domain engages C3G (Rattus norvegicus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF [extracellular region] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P25427 Ngf
Gene Names
Ngf, Ngfb
Chain
signal peptide:1-18, propeptide:19-121, chain:122-241
Reference Genes
BioGPS Gene:310738 Ngf
ENSEMBL:ENSRNOG00000016571 Ngf
KEGG Gene (Rattus norvegicus):310738 Ngf
Monarch:310738 Ngf
NCBI Gene:310738 Ngf
Reference Transcript
RefSeq:XM_006233053.2 Ngf
RefSeq:XM_006233052.3 Ngf
RefSeq:NM_001277055.1 Ngf
Other Identifiers
10817894
1371259_at
1598328
17741409
310738
5675749
5813355
6077928
6244483
6290529
A0A0G2K2Z7
A_42_P461587
A_64_P120699
AAA41697
ENSRNOG00000016571
ENSRNOP00000022200
ENSRNOT00000022200
EntrezGene:310738
EntrezGene:Ngf
GO:0000902
GO:0001934
GO:0003674
GO:0004857
GO:0005102
GO:0005163
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005768
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0006464
GO:0006950
GO:0006954
GO:0007165
GO:0007169
GO:0007267
GO:0007422
GO:0007568
GO:0007613
GO:0008021
GO:0008083
GO:0008150
GO:0008191
GO:0008219
GO:0008283
GO:0008284
GO:0008289
GO:0008344
GO:0009058
GO:0009314
GO:0009612
GO:0010033
GO:0010193
GO:0010466
GO:0010951
GO:0014070
GO:0019233
GO:0021675
GO:0030154
GO:0030234
GO:0030307
GO:0030414
GO:0030424
GO:0030425
GO:0031175
GO:0031410
GO:0031904
GO:0031954
GO:0032092
GO:0032496
GO:0034641
GO:0035094
GO:0038180
GO:0040007
GO:0042493
GO:0043226
GO:0043434
GO:0043524
GO:0045664
GO:0045666
GO:0048672
GO:0048812
GO:0048856
GO:0050804
GO:0050877
GO:0051091
GO:0051384
GO:0051388
GO:0051602
GO:0070374
GO:1902236
GO:2000648
GO:2000675
ILMN_1362230
IPR002072
IPR019846
IPR020408
IPR020425
IPR020437
IPR029034
M36589
Ngf
Ngf-201
NM_001277055
NP_001263984
PF00243
PH_rn_0005742
PR00268
PR01913
PR01925
rc_AI137043_at
SM00140
UPI000012FFFD
XM_006233052
XM_006233053
XP_006233114
XP_006233115
Participant Of
hasMember
NGF ligand [extracellular region]
hasComponent
beta-NGF homodimer [extracellular region]
Other forms of this molecule
mature beta-NGF [Golgi lumen]
pro-beta-NGF precursor [extracellular region]
NGF [cytosol]
beta-NGF pro-precursor [endoplasmic reticulum lumen]
beta-NGF precursor [Golgi lumen]
Inferred From
NGF [extracellular region] (Homo sapiens)
Cross References
RefSeq
XP_006233114.1
,
NP_001263984.1
,
XP_006233115.1
PRO
P25427
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