Shc, complexed with TrkA, is Tyrosine-phosphorylated

Stable Identifier
R-RNO-181799
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Shc, complexed with TrkA, is Tyrosine-phosphorylated
The human event is deduced on the basis of experiments in rat (Basu et al. 1994, Hallberg et al. 1998).
Literature References
PubMed ID Title Journal Year
7970708 Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor

Downward, J, Basu, T, Warne, PH

Oncogene 1994
9715270 Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase

Downward, J, Hallberg, B, Kaplan, DR, Ashcroft, M, Loeb, DM

Oncogene 1998
Participants
Input
Output
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of p-Trk receptor:Shc [plasma membrane]

Physical Entity
p-Trk receptor:Shc [plasma membrane] (Rattus norvegicus)
Activity
transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Orthologous Events
SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)
Authored
Jassal, B  (2006-06-20)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2006-06-20)
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