Reactome | Ghost homologue of PSME3 [nucleoplasm]

Cell Cycle (Rattus norvegicus)

- Cell Cycle, Mitotic (Rattus norvegicus)
  - Mitotic G1 phase and G1/S transition (Rattus norvegicus)
    - G1/S Transition (Rattus norvegicus)
      - Cyclin E associated events during G1/S transition (Rattus norvegicus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Rattus norvegicus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        Ghost homologue of PSME3 [nucleoplasm] (Rattus norvegicus)
  - Regulation of mitotic cell cycle (Rattus norvegicus)
    - APC/C-mediated degradation of cell cycle proteins (Rattus norvegicus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Rattus norvegicus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        Ghost homologue of PSME3 [nucleoplasm] (Rattus norvegicus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Rattus norvegicus)
        
        Degradation of multiubiquitinated Cdh1 (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        Ghost homologue of PSME3 [nucleoplasm] (Rattus norvegicus)
  - S Phase (Rattus norvegicus)
    - Cyclin A:Cdk2-associated events at S phase entry (Rattus norvegicus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Rattus norvegicus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        Ghost homologue of PSME3 [nucleoplasm] (Rattus norvegicus)

Cellular responses to stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Cellular response to chemical stress (Rattus norvegicus)
    - KEAP1-NFE2L2 pathway (Rattus norvegicus)
      - Nuclear events mediated by NFE2L2 (Rattus norvegicus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Rattus norvegicus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        Ghost homologue of PSME3 [nucleoplasm] (Rattus norvegicus)

DNA Replication (Rattus norvegicus)

- DNA Replication Pre-Initiation (Rattus norvegicus)
  - Assembly of the pre-replicative complex (Rattus norvegicus)
    - Ubiquitinated geminin is degraded by the proteasome (Rattus norvegicus)
      - 26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        Ghost homologue of PSME3 [nucleoplasm] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional regulation by RUNX3 (Rattus norvegicus)
      - Regulation of RUNX3 expression and activity (Rattus norvegicus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        Ghost homologue of PSME3 [nucleoplasm] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Hedgehog (Rattus norvegicus)
  - Hedgehog 'on' state (Rattus norvegicus)
    - GLI2,3 are degraded by the proteasome (Rattus norvegicus)
      - 26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        Ghost homologue of PSME3 [nucleoplasm] (Rattus norvegicus)