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Ldlrap1 [plasma membrane]
Stable Identifier
R-RNO-171143
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
LDLRAP1, D3ZAR1
Locations in the PathwayBrowser
Expand all
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Metabolism of steroids (Rattus norvegicus)
Vitamin D (calciferol) metabolism (Rattus norvegicus)
LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Rattus norvegicus)
LRP2:LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Rattus norvegicus)
Transport of RCbl within the body (Rattus norvegicus)
LRP2 binds extracellular TCN2:RCbl (Rattus norvegicus)
LRP2:LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
LRP2:LDLRAP1:TCN2:RCbl [plasma membrane] (Rattus norvegicus)
LRP2:LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Rattus norvegicus)
LRP2:LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
LRP2:LDLRAP1:TCN2:RCbl [plasma membrane] (Rattus norvegicus)
LRP2:LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
Transport of small molecules (Rattus norvegicus)
Plasma lipoprotein assembly, remodeling, and clearance (Rattus norvegicus)
Plasma lipoprotein clearance (Rattus norvegicus)
Chylomicron clearance (Rattus norvegicus)
chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
LDL clearance (Rattus norvegicus)
LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
Vesicle-mediated transport (Rattus norvegicus)
Membrane Trafficking (Rattus norvegicus)
Clathrin-mediated endocytosis (Rattus norvegicus)
BAR domain proteins recruit dynamin (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
LDLR is bound by DAB2 and ARH (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
Clathrin recruits PIK3C2A (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Rattus norvegicus)
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
Ldlrap1 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:D3ZAR1
Gene Names
Ldlrap1
Reference Genes
ENSEMBL:ENSRNOG00000000151
UCSC:D3ZAR1 Ldlrap1
Participates
as a member of
DAB2,LDLRAP1 [plasma membrane] (Rattus norvegicus)
as a component of
LRP2:LDLRAP1 [plasma membrane] (Rattus norvegicus)
This entity regulates
Positively
chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)
(Rattus norvegicus)
LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)
(Rattus norvegicus)
Other forms of this molecule
Ldlrap1 [clathrin-coated endocytic vesicle membrane]
Inferred From
LDLRAP1 [plasma membrane]
(Homo sapiens)
Cross References
PRO
D3ZAR1
RGD
1563417
PDB
3SO6
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01130 LDLR
4
LDLR [endolysosome membrane]
(R-HSA-6784818)
LDLR [endosome membrane]
(R-HSA-171127)
LDLR [clathrin-coated endocytic vesicle membrane]
(R-HSA-171105)
LDLR [plasma membrane]
(R-HSA-171053)
0.558
3
UniProt:P98158-PRO_0000017322 LRP2
0.508
3
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