2-acylglycerol + H2O -> glycerol + fatty acid

Stable Identifier
R-RNO-163439
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, lipid droplet
ReviewStatus
5/5
General
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2-acylglycerol + H2O -> glycerol + fatty acid
Rat monoacylglycerol lipase (MGLL) catalyzes the hydrolysis of 2-acylglycerol to yield glycerol + fatty acid (Tornqvist and Belfrage 1976; Fredrikson et al. 1986). Localization of the enzyme to lipid particles is plausible, given its low solubility and its involvement in acylglycerol metabolism, but this localization has not been directly experimentally verified. The human reaction is inferred from the well-studied rat one.
Literature References
PubMed ID Title Journal Year
3955067 Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol

Fredrikson, G, Tornqvist, H, Belfrage, P

Biochim Biophys Acta 1986
1249056 Purification and some properties of a monoacylglycerol-hydrolyzing enzyme of rat adipose tissue

Tornqvist, H, Belfrage, P

J Biol Chem 1976
Participants
Input
Output
Catalyst Activity

monoacylglycerol lipase activity of monoglyceride lipase [lipid droplet]

Physical Entity
monoglyceride lipase [lipid droplet] (Rattus norvegicus)
Activity
monoacylglycerol lipase activity (GO:0047372)
Orthologous Events
2-acylglycerol + H2O -> glycerol + fatty acid (Homo sapiens)
Authored
D'Eustachio, P  (2005-05-02)
Created
D'Eustachio, P  (2005-05-02)
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