Reactome | Gp6 [plasma membrane]

Gp6 [plasma membrane]

Stable Identifier

R-RNO-114574

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

GP6, M0R8A3

Locations in the PathwayBrowser

Expand all

Hemostasis (Rattus norvegicus)

- Cell surface interactions at the vascular wall (Rattus norvegicus)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
      - GP VI : FceRI gamma dimer [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
- Platelet Adhesion to exposed collagen (Rattus norvegicus)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
      - GP VI : FceRI gamma dimer [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
  - GPVI binds Fyn and Lyn (Rattus norvegicus)
    - GP VI : FceRI gamma dimer [plasma membrane] (Rattus norvegicus)
      - Gp6 [plasma membrane] (Rattus norvegicus)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
      - GP VI : FceRI gamma dimer [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
  - Interaction of GPVI and FceRI gamma (Rattus norvegicus)
    - GP VI : FceRI gamma dimer [plasma membrane] (Rattus norvegicus)
      - Gp6 [plasma membrane] (Rattus norvegicus)
    - Gp6 [plasma membrane] (Rattus norvegicus)
- Platelet activation, signaling and aggregation (Rattus norvegicus)
  - GPVI-mediated activation cascade (Rattus norvegicus)
    - Binding of Syk tyrosine kinase (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Rattus norvegicus)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
    - GPVI stimulates PI3K beta, gamma (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
    - SYK autophosphorylates (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
    - p-Y348-SYK dissociates (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Rattus norvegicus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Rattus norvegicus)
        
        Gp6 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:M0R8A3

Gene Names

Gp6

Reference Genes

ENSEMBL:ENSRNOG00000047204.4

Other Identifiers

17882353

17882354

GO:0005518

GO:0005886

GO:0007155

GO:0009986

GO:0023052

GO:0038063

GO:0038064

GO:0038065

GO:0042060

GO:0060089

GO:0070527

PH_rn_0016423

Participates

as an input of

Interaction of GPVI and FceRI gamma (Rattus norvegicus)

as a component of

Inferred From

GP6 [plasma membrane] (Homo sapiens)

Cross References

Ensembl

ENSRNOG00000047204, ENSRNOP00000065697, ENSRNOT00000071927

RGD

1589130

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