Cxxc4 binds DVL to prevent AXIN binding

Stable Identifier
R-NUL-5368583
Type
Reaction
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Cxxc4 binds DVL to prevent AXIN binding

Cxxc4 was identified as Idax in a two-hybrid screen of a rat library with a human DVL1 bait. Idax forms a complex with DVL in vivo and competes with AXIN for DVL binding. Expression of Idax in L-cells abrogates the WNT3a-induced expression of a TCF-dependent reporter gene, supporting a role for Idax as a negative regulator of WNT target gene expression (Hino et al, 2001).

Literature References
PubMed ID Title Journal Year
10944533 Inhibition of Wnt signaling pathway by a novel axin-binding protein

Kadoya, T, Kishida, S, Fukui, A, Hinoi, T, Michiue, T, Asashima, M, Kikuchi, A

J. Biol. Chem. 2000
Participants
Orthologous Events
Authored
Created
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