Inactivation of Cdc42

Stable Identifier
R-NUL-428519
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Inactivation of Cdc42
Human SRGAP, bound to the cytoplasmic tail of rat Robo1, increases the intrinsic GTPase activity of human CDC42, converting the GTP-bound form of CDC42 into its GDP-bound form, therefore inactivating CDC42 (Wong et al. 2001, Li et al. 2006).
Literature References
PubMed ID Title Journal Year
16857672 Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway

Bartlam, M, Li, X, Wu, JY, Liu, Y, Rao, Z, Gao, F, Gao, J, Chen, Y

J Biol Chem 2006
11672528 Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway

Brady-Kalnay, SM, Tang, H, Xie, Y, Wen, L, Mei, L, Wu, JY, Ren, XR, Rao, Y, Saito, H, Wong, K, Xiong, WC, Liu, G, Huang, YZ

Cell 2001
Participants
Catalyst Activity

GTPase activator activity of Robo1:Slit2:SrGAP [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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