DCC heterodimerizes with Unc-5:Netrin-1

Stable Identifier
R-NUL-421695
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
DCC heterodimerizes with Unc-5:Netrin-1
UNC-5 uses DCC as a co-receptor and binds to the DCC P1 domain with its DB domain to repel axons at low netrin concentration. It is generally thought that UNC5 receptor alone transduces short range signals whereas DCC-Unc5 complex transduces long range signals important for neuron migration, neurite growth and axon repulsion.
Literature References
PubMed ID Title Journal Year
15960985 The Netrin family of guidance factors: emphasis on Netrin-1 signalling

Barallobre, MJ, Pascual, M, Soriano, E, Del Rio, JA

Brain Res Brain Res Rev 2005
10399920 A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion

Nishiyama, M, Stein, E, Hinck, L, Tessier-Lavigne, M, Hong, K, Poo, MM

Cell 1999
Participants
Orthologous Events
Authored
Reviewed
Created
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