Reactome | Klc1 [cytosol]

Klc1 [cytosol]

Stable Identifier

R-MMU-983284

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

KLC1, O88447

Locations in the PathwayBrowser

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Signal Transduction (Mus musculus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases activate KTN1 (Mus musculus)
        
        KTN1 binds Kinesin-1 (Mus musculus)
        
        Kinesin-1 [cytosol] (Mus musculus)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Mus musculus)
        
        Klc1 [cytosol] (Mus musculus)
        
        RHOA,RHOG,RAC1,CDC42:GTP:KTN1:Kinesin-1 [endoplasmic reticulum membrane] (Mus musculus)
        
        Kinesin-1 [cytosol] (Mus musculus)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Mus musculus)
        
        Klc1 [cytosol] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Mus musculus)
    - Golgi-to-ER retrograde transport (Mus musculus)
      - COPI-dependent Golgi-to-ER retrograde traffic (Mus musculus)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Mus musculus)
        
        Kinesins:microtubule [cytosol] (Mus musculus)
        
        Kinesins [cytosol] (Mus musculus)
        
        Kinesin-1 [cytosol] (Mus musculus)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Mus musculus)
        
        Klc1 [cytosol] (Mus musculus)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Mus musculus)
        
        Kinesins:microtubule [cytosol] (Mus musculus)
        
        Kinesins [cytosol] (Mus musculus)
        
        Kinesin-1 [cytosol] (Mus musculus)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Mus musculus)
        
        Klc1 [cytosol] (Mus musculus)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Mus musculus)
        
        Kinesins:microtubule [cytosol] (Mus musculus)
        
        Kinesins [cytosol] (Mus musculus)
        
        Kinesin-1 [cytosol] (Mus musculus)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Mus musculus)
        
        Klc1 [cytosol] (Mus musculus)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Mus musculus)
        
        Kinesins:microtubule [cytosol] (Mus musculus)
        
        Kinesins [cytosol] (Mus musculus)
        
        Kinesin-1 [cytosol] (Mus musculus)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Mus musculus)
        
        Klc1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:O88447

Gene Names

Klc1

Reference Genes

ENSEMBL:ENSMUSG00000021288

Participates

as a member of

KLC1,KLC2,KLC3,KLC4 [cytosol] (Mus musculus)

Inferred From

KLC1 [cytosol] (Homo sapiens)

Cross References

PRO

O88447

MGI

107978

PDB

6FUZ, 6FV0

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q58A65 Spag9	1	JIP4_MOUSE [cytosol] (R-MMU-448828)	0.581	6
UniProt:P63017 Hspa8	10	Me3K561-HSPA8 [nucleoplasm] (R-MMU-8932217) HSPA8 [nucleoplasm] (R-MMU-5082380) HSPA8 [secretory granule lumen] (R-MMU-6801530) HSPA8 [extracellular region] (R-MMU-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-MMU-6801494) HSPA8 [plasma membrane] (R-MMU-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-MMU-888599) Hspa8 [late endosome lumen] (R-MMU-9631087) Hspa8 [cytosol] (R-MMU-9613512) HSPA8 [cytosol] (R-MMU-264476)	0.499	3