Activators bind Stat5

Stable Identifier
R-MMU-9645128
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Activators bind Stat5
Signal transducer and activator of transcription (Stat5a/Stat5b) is a key component in several cell signaling and gene transcription process and regulated cell survival and proliferation. Stat5 is activated by multiple upstream activators including cytokines and growth factors. The process begins when an active upstream regulator binds Stat5 to initiate its phosphorylation (Sarah C et al, 2013).
Literature References
PubMed ID Title Journal Year
23103841 The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Boswell, HS, Ramdas, B, Feng, GS, Zeng, L, Kapur, R, He, Y, Liu, Z, Zhang, X, Sandusky, GE, Zhang, ZY, Fukuda, S, Li, XJ, Nabinger, SC, Yu, M, Richine, B, Chan, RJ, Goenka, S, Bowling, JD

Leukemia 2013
Participants
Orthologous Events
Authored
Reviewed
Created
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