Irak1 gene expression is inhibited by Mecp2

Stable Identifier
R-MMU-9615830
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Irak1 gene expression is inhibited by Mecp2
In mouse cortical neurons, Mecp2 represses Irak1 gene transcription. Irak1, a serine/threonine protein kinase that activates Nfkb-mediated transcription, is upregulated in the cortex of Mecp2 null mice. Some of the Rett syndorome features, such as reduced dendritic complexity and decreased life span, can be ameliorated by attenuation of Nfkb signaling (Kishi et al. 2016).
Literature References
PubMed ID Title Journal Year
26821816 Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

Ye, J, Macklis, JD, Kishi, N, MacDonald, JL, Azim, E, Molyneaux, BJ

Nat Commun 2016
Participants
Input
Output
Orthologous Events
IRAK1 gene expression is inhibited by MECP2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-08-08)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2018-08-08)
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