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TOP3A [nucleoplasm]
Stable Identifier
R-MMU-912452
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
O70157
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
G2/M Checkpoints (Mus musculus)
G2/M DNA damage checkpoint (Mus musculus)
ATR phosphorylates TP53 (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
Homology Directed Repair (Mus musculus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
HDR through Homologous Recombination (HRR) (Mus musculus)
D-loop extension by DNA polymerases (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Homologous DNA Pairing and Strand Exchange (Mus musculus)
CX3 complex binds D-loop structures (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
D-loop formation mediated by PALB2, BRCA2 and RAD51 (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Presynaptic phase of homologous DNA pairing and strand exchange (Mus musculus)
BCDX2 complex stabilizes RAD51 filament (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Resolution of D-Loop Structures (Mus musculus)
Resolution of D-loop Structures through Holliday Junction Intermediates (Mus musculus)
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Ligation of DNA and formation of Holliday structures following repair synthesis (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
MUS81:EME1,EME2 cleaves D-loop (Mus musculus)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
SPIDR binds BLM:TOP3A:RMI1:RMI2 (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2:SPIDR [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
HDR through Single Strand Annealing (SSA) (Mus musculus)
Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Association of RAD52 with the RPA complex at resected DNA DSBs (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
ERCC1:XPF cleaves flaps generated by SSA (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Processing of DNA double-strand break ends (Mus musculus)
ATR activation at DNA DSBs (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
ATR phosphorylates RPA2 (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Activation of CHEK1 at resected DNA DSBs (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Association of RPA complexes with ssDNA at resected DNA DSBs (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Binding of ATR:ATRIP to RPA at resected DNA DSBs (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
CHEK1 is recruited to resected DNA DSBs (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Mus musculus)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Activity through Phosphorylation (Mus musculus)
ATR phosphorylates TP53 (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
TOP3A [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:O70157 Top3a
Gene Names
Top3a, Top3
Chain
chain:1-1003
Reference Genes
BioGPS Gene:21975 Top3a
ENSEMBL:ENSMUSG00000002814.16 Top3a
KEGG Gene (Mus musculus):21975 Top3a
Monarch:21975 Top3a
NCBI Gene:21975 Top3a
UCSC:O70157 Top3a
Reference Transcript
RefSeq:NM_009410.2 Top3a
Other Identifiers
10386582
1418597_at
17263642
21975
4427446
4442876
4452728
4459410
4509874
4529648
4539380
4564116
4589425
4654339
4673254
4695947
4829192
4848246
4876028
5031907
5141412
5158195
5293175
5398137
5405713
5485544
5497957
5519392
5542957
5590694
94124_at
A_51_P203451
A_55_P1953578
GE33832
GO:0000724
GO:0003677
GO:0003697
GO:0003824
GO:0003916
GO:0003917
GO:0005634
GO:0005654
GO:0005694
GO:0005739
GO:0005759
GO:0006265
GO:0006281
GO:0006310
GO:0007005
GO:0007059
GO:0008270
GO:0016605
GO:0016853
GO:0031422
GO:0032042
GO:0043226
GO:0046872
GO:0051304
GO:0071139
GO:0140097
ILMN_1249579
mMR027960
Participates
as a component of
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
Other forms of this molecule
DNA topoisomerase 3-alpha [nucleoplasm]
Inferred From
TOP3A [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_033436.1
Ensembl
ENSMUSP00000002891
,
ENSMUST00000002891
,
ENSMUSG00000002814
PRO
O70157
MGI
1197527
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