Notch3 coactivator complex binds the Heyl gene promoter

Stable Identifier
R-MMU-9017420
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Notch3 coactivator complex binds the Heyl gene promoter

Mouse Rbpj, a component of the Notch3 coactivator complex, binds to Rbpj response elements in the promoter of the mouse Heyl gene (Geimer Le Lay et al. 2014). Transcription from the human HEYL gene is stimulated by mouse Notch3 (Maier and Gessler 2000). Heyl gene expression overlaps with Notch3 expression in mouse vascular smooth muscle cells and mouse thymus (Leimeister et al. 2000). It can therefore be concluded that the Notch3 coactivator complex binds the promoter of the Heyl gene.

Literature References
PubMed ID Title Journal Year
10964718 Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

Maier, MM, Gessler, M

Biochem Biophys Res Commun 2000
11044625 Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos

Leimeister, C, Schumacher, N, Steidl, C, Gessler, M

Mech Dev 2000
24643801 The tumor suppressor Ikaros shapes the repertoire of notch target genes in T cells

Geimer Le Lay, AS, Oravecz, A, Mastio, J, Jung, C, Marchal, P, Ebel, C, Dembélé, D, Jost, B, Le Gras, S, Thibault, C, Borggrefe, T, Kastner, P, Chan, S

Sci Signal 2014
Participants
Orthologous Events
Authored
Reviewed
Created
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