Notch3 coactivator complex binds the Ptcra gene promoter

Stable Identifier
R-MMU-9016915
Type
Reaction
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Notch3 coactivator complex binds the Ptcra gene promoter

Mouse Rbpj transcription factor directly binds to Rbpj/Csl elements in the promoter of the Ptcra gene, encoding Pre-TCR-alpha. As Notch3 intracellular domain and Maml proteins are also needed for induction of the Ptcra gene transcription, it is plausible that Rbpj binds to the Ptcra promoter in the context of the Notch3 coactivator complex (Bellavia et al. 2007).

Literature References
PubMed ID Title Journal Year
17332745 Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing

Bellavia, D, Mecarozzi, M, Campese, AF, Grazioli, P, Talora, C, Frati, L, Gulino, A, Screpanti, I

EMBO J. 2007
Participants
Orthologous Events
Authored
Reviewed
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