Jak2, Tyk2 in Il12b:Il23a:Il12rb1:Tyk2:Il23r:Jak2 are phosphorylated

Stable Identifier
R-MMU-8950612
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
Jak2 and Tyk2 activation after Il23:Il23r interaction
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Jak2, Tyk2 in Il12b:Il23a:Il12rb1:Tyk2:Il23r:Jak2 are phosphorylated
The intracellular domain of Interleukin-12 receptor beta 1 subunit (Il12rb1) spanning amino acid residues 592–656 is crucial for Interleukin-23 complex–induced cellular proliferation and Signal transducer and activator of transcription 3 (Stat3) phosphorylation (Floss et al. 2016).
As it is not clear about the pattern of phosphorylations this reaction is represented here as a black box event.
Literature References
PubMed ID Title Journal Year
27193299 Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases

Lamertz, L, Floss, DM, Hermanns, H, Scheller, J, Schröder, J, Mrotzek, S, Strobl, B, Klöcker, T

Mol. Biol. Cell 2016
Participants
Input
Output
Orthologous Events
JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)
Authored
Duenas, C  (2016-12-02)
Reviewed
van de Vosse, E  (2017-05-12)
Created
Duenas, C  (2016-12-02)
Cite Us!