Rorc gene expression is stimulated by Runx3:Cbfb

Stable Identifier
R-MMU-8949303
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rorc gene expression is stimulated by Runx3:Cbfb
The Runx3:Cbfb heterodimer binds the Runx binding motif TGTGGT in the promoter of the mouse Rorc (Ror-gamma) gene and stimulates transcription of the Rorc transcript variant 2 (Rorc-2), also known as RORgT (RORgamma-t). Human RUNX3 can also stimulate transcription of the mouse Rorc gene. In the ILC3 lineage of innate lymphoid cells in mice, expression of the Ahr transcription factor is positively indirectly regulated by Runx3, most likely through RORgT (Ebihara et al. 2015).
Literature References
PubMed ID Title Journal Year
26414766 Runx3 specifies lineage commitment of innate lymphoid cells

Stappenbeck, TS, Yang, L, Egawa, T, Yokoyama, WM, Ebihara, T, Groner, Y, Plougastel-Douglas, B, Bern, MD, Song, C, Colonna, M, Ryu, SH, Levanon, D

Nat. Immunol. 2015
Participants
Input
Output
This event is regulated
Positively by
Regulator
Runx3:Cbfb:Rorc gene [nucleoplasm] (Mus musculus)
Active Unit
Runx3:Cbfb [nucleoplasm]
Orthologous Events
RORC gene expression is stimulated by RUNX3:CBFB (Homo sapiens)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-11-21)
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