Reactome | Rpl7 [cytosol]

Rpl7 [cytosol]

Stable Identifier

R-MMU-72486

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RPL7, P14148

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl7 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl7 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl7 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl7 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl7 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl7 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl7 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl7 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl7 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl7 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P14148 Rpl7

Gene Names

Rpl7

Chain

chain:1-270

Reference Genes

BioGPS Gene:19989 Rpl7

ENSEMBL:ENSMUSG00000043716.14 Rpl7

KEGG Gene (Mus musculus):19989 Rpl7

Monarch:19989 Rpl7

NCBI Gene:19989 Rpl7

UCSC:P14148 Rpl7

Reference Transcript

RefSeq:NM_011291.5 Rpl7

Other Identifiers

10353265

10375461

10521593

10522782

1415979_x_at

1426162_a_at

17221454

17547573

19989

4324687

4435791

4450284

4534861

4578161

4764940

4784270

4796643

4849193

4868824

5001622

5039902

5050962

5168119

5318658

5396330

5476827

5579856

97695_s_at

A_51_P496480

A_52_P346326

A_52_P455580

A_55_P2909620

GE1504964

GE36021

GO:0000463

GO:0002181

GO:0003677

GO:0003723

GO:0003729

GO:0003735

GO:0005198

GO:0005737

GO:0005829

GO:0005840

GO:0005844

GO:0006364

GO:0006412

GO:0008097

GO:0014069

GO:0022625

GO:0022626

GO:0031672

GO:0042254

GO:0042273

GO:0042802

GO:0043226

GO:0045202

GO:0098793

GO:0098794

GO:0140236

GO:0140242

GO:1990904

ILMN_2646163

M85235_f_at

mMC023558

Participates

as a component of

Other forms of this molecule

Rpl7 [cytosol]

Inferred From

RPL7 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_035421.2

Ensembl

ENSMUST00000058437, ENSMUSG00000043716, ENSMUSP00000071616

PRO

P14148

MGI

98073

PDB

7CPU, 6SWA, 7LS2, 7CPV, 7LS1

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