Reactome | Rpl27a [cytosol]

Rpl27a [cytosol]

Stable Identifier

R-MMU-72442

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RPL27A, P14115

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl27a [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl27a [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl27a [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl27a [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl27a [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl27a [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl27a [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl27a [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl27a [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl27a [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P14115 Rpl27a

Gene Names

Rpl27a

Chain

chain:1-148

Reference Genes

BioGPS Gene:26451 Rpl27a

ENSEMBL:ENSMUSG00000046364.15 Rpl27a

KEGG Gene (Mus musculus):26451 Rpl27a

Monarch:26451 Rpl27a

NCBI Gene:26451 Rpl27a

UCSC:P14115 Rpl27a

Reference Transcript

RefSeq:NM_011975.3 Rpl27a

Other Identifiers

101573_f_at

101680_at

10357369

10363479

10406854

10474669

10487643

10491062

10547151

10556200

10578064

1426661_at

17396336

17481673

26451

4456438

4481307

4703972

4708136

4715666

4723780

4736114

4846649

4865744

4908280

5122382

5225990

5226989

5393411

5480584

5489590

5504707

5538531

5546667

96630_at

A_51_P132459

A_55_P2065327

GE119606

GE39554

GO:0002181

GO:0003735

GO:0005198

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0006412

GO:0015934

GO:0022625

GO:0022626

GO:0043226

GO:0045202

GO:0098793

GO:0098794

GO:0140236

GO:0140242

GO:1990904

ILMN_1215659

ILMN_1221403

ILMN_1227653

ILMN_2641304

ILMN_2882059

Msa.2195.0_f_at

X05021_f_at

mMC013122

mMC020246

mMR027706

Participates

as a component of

Other forms of this molecule

Rpl27a [nucleoplasm]

Rpl27a [cytosol]

Inferred From

RPL27A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_036105.2

Ensembl

ENSMUSG00000046364, ENSMUSP00000123410, ENSMUST00000143107

PRO

P14115

MGI

1347076

PDB

7CPU, 7LS1, 6SWA, 7LS2, 7CPV

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