Reactome | Rpl10 [cytosol]

Rpl10 [cytosol]

Stable Identifier

R-MMU-72402

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RPL10, Q6ZWV3

Locations in the PathwayBrowser

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Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL10,RPL10L [cytosol] (Mus musculus)
        
        Rpl10 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL10,RPL10L [cytosol] (Mus musculus)
        
        Rpl10 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL10,RPL10L [cytosol] (Mus musculus)
        
        Rpl10 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL10,RPL10L [cytosol] (Mus musculus)
        
        Rpl10 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL10,RPL10L [cytosol] (Mus musculus)
        
        Rpl10 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL10,RPL10L [cytosol] (Mus musculus)
        
        Rpl10 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL10,RPL10L [cytosol] (Mus musculus)
        
        Rpl10 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL10,RPL10L [cytosol] (Mus musculus)
        
        Rpl10 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL10,RPL10L [cytosol] (Mus musculus)
        
        Rpl10 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL10,RPL10L [cytosol] (Mus musculus)
        
        Rpl10 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6ZWV3 Rpl10

Gene Names

Rpl10, Qm

Chain

chain:1-214

Reference Genes

BioGPS Gene:110954 Rpl10

ENSEMBL:ENSMUSG00000008682.14 Rpl10

ENSEMBL:ENSMUSG00000058443.6 Rpl10

KEGG Gene (Mus musculus):110954 Rpl10

Monarch:110954 Rpl10

NCBI Gene:110954 Rpl10

UCSC:Q6ZWV3 Rpl10

Reference Transcript

RefSeq:NM_052835.3 Rpl10

Other Identifiers

10467256

10485654

10581505

10593320

10596379

10600349

110954

1415942_at

1448157_s_at

17526805

17535767

4456171

4581892

4590146

4643734

4660106

4688367

4696532

4698751

4699426

4823099

4902519

4914400

4992272

5052550

5069454

5076788

5124930

5204043

5323736

5327586

5507592

5545979

5557229

5579427

98342_at

A_51_P495895

A_55_P2142191

GO:0000027

GO:0000122

GO:0003735

GO:0005198

GO:0005634

GO:0005737

GO:0005783

GO:0005790

GO:0005829

GO:0005840

GO:0006351

GO:0006355

GO:0006412

GO:0006417

GO:0012501

GO:0022625

GO:0022626

GO:0032991

GO:0042254

GO:0043066

GO:0043226

GO:0045182

GO:0045202

GO:0048856

GO:0065003

GO:0097421

GO:0098793

GO:0098794

GO:0140236

GO:0140242

GO:1990403

GO:1990904

ILMN_2740432

m93980_f_at

mMC022268

Participates

as a member of

RPL10,RPL10L [cytosol] (Mus musculus)

Other forms of this molecule

Rpl10 [cytosol]

Inferred From

RPL10 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_443067.1

Ensembl

ENSMUST00000074085, ENSMUSG00000008682, ENSMUSG00000058443, ENSMUST00000076364, ENSMUSP00000008826, ENSMUST00000008826, ENSMUSP00000082055, ENSMUSP00000125806

PRO

Q6ZWV3

MGI

105943

PDB

7CPU, 6SWA

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