Reactome | Socs5 [cytosol]

Socs5 [cytosol]

Stable Identifier

R-MMU-6788342

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

SOCS5, O54928

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-4 and Interleukin-13 signaling (Mus musculus)
      - SOCS5,(SOCS1) bind IL4RA (Mus musculus)
        
        IL4:IL4R:JAK2:IL13RA:TYK2:SOCS5,(SOCS1) [plasma membrane] (Mus musculus)
        
        SOCS5,(SOCS1) [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)
        
        SOCS5,(SOCS1) [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Socs5 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:O54928

Gene Names

Socs5

Reference Genes

BioGPS Gene:56468 Socs5

ENSEMBL:ENSMUSG00000037104

ENSEMBL:ENSMUSG00000037104.10 Socs5

KEGG Gene (Mus musculus):56468 Socs5

Monarch:56468 Socs5

NCBI Gene:56468 Socs5

UCSC:O54928 Socs5

Reference Transcript

Other Identifiers

10447356

132049_at

1423349_at

1423350_at

1441640_at

163474_at

17340239

4622768

4646966

4874619

4941696

4973786

5078354

5174854

5285927

5582154

56468

92287_at

A_52_P281033

A_55_P2734257

GE116407

GE37607

GO:0002376

GO:0005154

GO:0005515

GO:0005737

GO:0005942

GO:0006629

GO:0006954

GO:0007155

GO:0007173

GO:0007175

GO:0007259

GO:0009968

GO:0016567

GO:0019210

GO:0019221

GO:0023052

GO:0030154

GO:0030163

GO:0030971

GO:0032436

GO:0032715

GO:0035556

GO:0036211

GO:0045627

GO:0045629

GO:0046854

GO:0046935

GO:0048856

GO:0050728

GO:0071404

GO:0071638

GO:0097699

GO:0098772

GO:1904988

ILMN_1231319

ILMN_1240346

mMC002746

Participates

as a member of

Inferred From

SOCS5 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006524737.1, NP_062628.2, XP_006524735.1, XP_006524734.1, XP_006524738.1

Ensembl

ENSMUST00000041369, ENSMUSG00000037104, ENSMUSP00000038591

PRO

O54928

MGI

2385459

PDB

2N34

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