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Isy1 [nucleoplasm]
Stable Identifier
R-MMU-6781963
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
ISY1, Q69ZQ2
Locations in the PathwayBrowser
Expand all
DNA Repair (Mus musculus)
Nucleotide Excision Repair (Mus musculus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Mus musculus)
Dual incision in TC-NER (Mus musculus)
3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)
TC-NER incision complex [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)
TC-NER incision complex [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
ERCC5 and RPA bind TC-NER site (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
Formation of TC-NER Pre-Incision Complex (Mus musculus)
Assembly of the pre-incision complex in TC-NER (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)
TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Mus musculus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Mus musculus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
Metabolism of RNA (Mus musculus)
Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
mRNA Splicing (Mus musculus)
mRNA Splicing - Major Pathway (Mus musculus)
Formation of the Spliceosomal Bact complex (Mus musculus)
PRP19-CDC5L related complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
PRP19-CDC5L related complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
Formation of the Spliceosomal C* complex (Mus musculus)
Spliceosomal C complex [nucleoplasm] (Mus musculus)
PRP19-CDC5L related complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
Spliceosomal C* complex [nucleoplasm] (Mus musculus)
PRP19-CDC5L related complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
Formation of the Spliceosomal P complex and exon ligation (Mus musculus)
Spliceosomal C* complex [nucleoplasm] (Mus musculus)
PRP19-CDC5L related complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
Spliceosomal P complex [nucleoplasm] (Mus musculus)
PRP19-CDC5L related complex [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q69ZQ2
Gene Names
Isy1
Reference Genes
BioGPS Gene:57905 Isy1
ENSEMBL:ENSMUSG00000030056
ENSEMBL:ENSMUSG00000030056.9 Isy1
KEGG Gene (Mus musculus):57905 Isy1
Monarch:57905 Isy1
NCBI Gene:57905 Isy1
UCSC:Q69ZQ2 Isy1
Reference Transcript
RefSeq:NM_133934.4 Isy1
Other Identifiers
10546066
109109_at
138046_at
1419357_at
1459728_at
17468678
4322345
4667027
4711497
4750041
4756039
4764952
4771540
4829112
4846092
4889216
4941261
5038275
5144548
5162234
5225553
5243839
5266415
5272180
5302513
5341300
5377824
5524913
5543527
57905
A_51_P493946
A_52_P660242
GE1529260
GE40162
GO:0000350
GO:0000389
GO:0000398
GO:0000974
GO:0005634
GO:0005681
GO:0006397
GO:0008380
GO:0016071
GO:0043226
GO:0065003
GO:0071006
GO:0071013
GO:0071014
GO:0071020
ILMN_2607769
ILMN_2828838
ILMN_3076397
mMC021809
Participates
as a component of
PRP19-CDC5L related complex [nucleoplasm] (Mus musculus)
XAB2 complex [nucleoplasm] (Mus musculus)
Inferred From
ISY1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_598695.1
Ensembl
ENSMUSP00000086923
,
ENSMUSG00000030056
,
ENSMUST00000089497
PRO
Q69ZQ2
MGI
1923310
PDB
1X4T
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